Genotyping of single nucleotide polymorphism by probe-gated silica nanoparticles.

The development of simple, reliable, and rapid approaches for molecular detection of common mutations is important for prevention and early diagnosis of genetic diseases, including Thalessemia. Oligonucleotide-gated mesoporous nanoparticles-based analysis is a new platform for mutation detection that has the advantages of sensitivity, rapidity, accuracy, and convenience. A specific mutation in β-thalassemia, one of the most prevalent inherited diseases in several countries, was used as model disease in this study.

Effects of cigarette smoking on hemorheologic parameters, plasma osmolality and lung function.

Background: Cigarette smoking deteriorates human health via vascular disorders, cancer and especially respiratory diseases. The aim of this study is to investigate effects of cigarette smoking on hemorheologic parameters, plasma osmolality and lung function in individuals without diagnosis of chronic obstructive pulmonary disease (COPD).

Methods: Patients diagnosed without COPD utilizing respiratory function test were enrolled in the study with three groups, ex-smokers (n = 21), current-smokers (n = 35) and never-smokers (n = 43).

Blood viscosity as a forgotten factor and its effect on pulmonary flow.

Background: The effect of smoking on blood viscosity is widely known. There are, however, few studies on the effect of blood viscosity on pulmonary circulation.

Methods: We aimed to observe the relationship between blood viscosity and pulmonary circulation among smokers and non-smokers.

The evaluation of plasma viscosity and endothelial dysfunction in smoking individuals.

Background: Smoking is considered to be one the of risk factors effecting atherosclerosis which is associated the physical forces, biological and chemical stimuli occuring in vessel wall. The aim of this study is analysis of the biomechanical (plasma viscosity) and biochemical effect (nitric oxide, NOx; asymmetric dimethylarginine, ADMA) of smoking on endothelial function.

Methods: One hundred-twenty two individuals were divided into three groups according to their smoking status.

Comparison of plasma viscosity as a marker of endothelial dysfunction with nitric oxide and asymmetric dimethylarginine in subjects with dyslipidemia.

Objective: In this study, we aimed to investigate the alterations in plasma viscosity and whether there was a relationship between plasma viscosity and endothelial dysfunction markers such as nitric oxide (NOx), asymmetric dimethylarginine (ADMA) and oxidized Low Density Lipoprotein (oxLDL) in dyslipidemic subjects.

Material And Method: 35 subjects with normolipidemia and 30 subjects with hyperlipidemia were involved in this study. Dyslipidemia was defined as total cholesterol levels ≥200 mg/dL and/or triglyceride level ≥150 mg/dL.

[Analysis of the alterations of trace elements in plasma and tissue, in lung cancer].

In our research, we aimed to analyse the relationship between the lung cancer and the zinc (Zn) and the copper (Cu) which are important trace elements for the organisms in cases containing lung cancer. The research included 20 patients who have been operated as a result of primary lung cancer. In the research, the Zn and Cu and Cu/Zn levels in the patient's cancerous and normal lung tissues and serum (pre-operative, post-operative day first and day fifth) were measured (pre-operative, post-operative day first and post-operative day fifth serum albumin levels were also measured).

Ezetimibe therapy and its influence on oxidative stress and fibrinolytic activity.

Objective: The effect of ezetimibe on blood lipids, oxidative stress, and fibrinolytic activity in hyperlipidemic patients was investigated after three months of therapy.

Methods: Thirty hyperlipidemic patients were treated for twelve weeks with ezetimibe 10 mg/day. A healthy control group with matching age and gender was also included.

The effect of β-glucan on trace element levels in intra-abdominal sepsis in rats.

Sepsis is associated with the development of progressive damage in multiple organ systems. The beneficial effect of glucans has been attributed to modulation of immune function and enhances defense against bacterial, viral, fungal, and parasitic infections. The aim of this study was to investigate the putative protective effect of ß-glucan on changes of trace element levels in various tissues after experimental sepsis in rats.

Abdominal aortic aneurysm or aortic occlusive disease: role of trace element imbalance.

The nature of the relationship between atheromatous disease and degenerative aneurysm is yet to be defined. The purpose of this study was to compare tissue Fe, Cu, Zn, and thiobarbituric acid reactive substances (TBARS) levels (as a marker of lipid peroxidation) in the abdominal aorta in relation to the development of aneurysmal and occlusive disease in the infrarenal aorta. This was a prospective clinical study in an institutional referral center, in hospitalized patients.

Association of plasma viscosity with cardiovascular risk factors in obesity: an old marker, a new insight.

Objective: Although obesity is related with cardiovascular disease, the exact mechanism of the relationship is not fully understood. We aim to examine the relationship between plasma viscosity and obesity as a cardiovascular disease risk factor in obese and non-obese groups.

Methods: We recruited 75 obese subjects (mean age: 40.

Relationship between plasma leptin and zinc levels and the effect of insulin and oxidative stress on leptin levels in obese diabetic patients.

Leptin is thought to be a lipostatic signal that contributes to body weight regulation. Zinc plays an important role in appetite regulation also. Our aim is to evaluate the relationship between leptin and zinc in obese and nonobese type 2 diabetic patients and its relationship with oxidative stress and insulin.

The altered hemorheologic parameters in thromboangiitis obliterans: a new insight.

The hemorheologic abnormalities were studied in patients suffering from thromboangiitis obliterans (TAO) and compared findings with those of patients suffering from critical limb ischemia because of peripheral atherosclerotic obstructive disease (PAOD) and the healthy subjects. This prospective study included 20 patients with TAO, 20 patients with PAOD, and 20 healthy subjects. Hematocrit, plasma fibrinogen, red blood cell rigidity, and blood and plasma viscosity were determined in all groups.

Plasma viscosity as an early cardiovascular risk factor in hirsute women with eumenorrhea or oligomenorrhea.

To investigate plasma viscosity, a hemorheologic variable, in oligomenorrheic and eumenorrheic hirsute women.Descriptive study. Endocrinology and metabolism clinic.

Plasma homocysteine levels in obese and non-obese subjects with or without hypertension; its relationship with oxidative stress and copper.

Objectives: The relationship between plasma total Homocysteine (tHcy) and oxidative stress and plasma levels of lipids, insulin and copper levels were investigated in obese and nonobese hypertensives.

Design And Methods: Plasma tHcy levels were determined by an enzyme immunoassay method. Plasma lipid peroxidation levels were measured as thiobarbituric acid reactive substances (TBARS) by spectrophotometric methods.

Effects of hemorheological factors on the development of hypertension in diabetic children.

The aim of this study was to investigate the effects of hemorheological factors on the development of hypertension in diabetic children without retinopathy and persistent microalbuminuria. Arterial blood pressures were measured in 46 diabetic children and were compared with those of 29 healthy non-obese and 32 obese age- and sex-matched children. Higher systolic (SBP) (109.

The effects of cholesterol levels on hemorheological parameters in diabetic patients.

Red blood cell (RBC) deformability is an important hemorheological parameter to determine the passage of RBC through narrow capillaries and the reduction of blood viscosity under high shear rates. Although it has been substantial evidence that diabetes mellitus (DM) and hypercholesterolemia increase the risk of coronary heart disease, the mechanism is unclear. In this study the relationship between hemorheological parameters and plasma cholesterol in type 2 diabetic patients (n=55, mean age 43.