Bioengineered gold nanoparticles targeted to mesenchymal cells from patients with bronchiolitis obliterans syndrome does not rise the inflammatory response and can be safely inhaled by rodents.

The use of gold nanoparticles (GNPs) as drug delivery system represents a promising issue for diseases without effective pharmacological treatment due to insufficient local drug accumulation and excessive systemic toxicity. Bronchiolitis obliterans syndrome (BOS) represents about 70% of cases of chronic lung allograft dysfunction, the main challenge to long-term lung transplantation. It is believed that due to repeated insults to epithelial bronchiolar cells local inflammatory response creates a milieu that favors epithelial-mesenchymal transition and activation of local mesenchymal cells (MCs) leading to airway fibro-obliteration.

Search for triboson [Formula: see text] production in collisions at [Formula: see text] [Formula: see text] with the ATLAS detector.

This paper reports a search for triboson [Formula: see text] production in two decay channels ([Formula: see text] and [Formula: see text] with [Formula: see text]) in proton-proton collision data corresponding to an integrated luminosity of 20.3 [Formula: see text] at a centre-of-mass energy of 8 [Formula: see text] with the ATLAS detector at the Large Hadron Collider. Events with exactly three charged leptons, or two leptons with the same electric charge in association with two jets, are selected.

Measurement of the prompt /[Formula: see text] pair production cross-section in collisions at [Formula: see text] TeV with the ATLAS detector.

The production of two prompt [Formula: see text] mesons, each with transverse momenta [Formula: see text] GeV and rapidity [Formula: see text], is studied using a sample of proton-proton collisions at [Formula: see text] TeV, corresponding to an integrated luminosity of 11.4 fb[Formula: see text] collected in 2012 with the ATLAS detector at the LHC. The differential cross-section, assuming unpolarised [Formula: see text] production, is measured as a function of the transverse momentum of the lower-[Formula: see text] [Formula: see text] meson, di-[Formula: see text] [Formula: see text] and mass, the difference in rapidity between the two [Formula: see text] mesons, and the azimuthal angle between the two [Formula: see text] mesons.

Measurement of the [Formula: see text] and [Formula: see text] production cross sections in multilepton final states using 3.2 fb[Formula: see text] of [Formula: see text] collisions at [Formula: see text] = 13 TeV with the ATLAS detector.

A measurement of the [Formula: see text] and [Formula: see text] production cross sections in final states with either two same-charge muons, or three or four leptons (electrons or muons) is presented. The analysis uses a data sample of proton-proton collisions at [Formula: see text] TeV recorded with the ATLAS detector at the Large Hadron Collider in 2015, corresponding to a total integrated luminosity of 3.2 fb[Formula: see text].

A measurement of the calorimeter response to single hadrons and determination of the jet energy scale uncertainty using LHC Run-1 -collision data with the ATLAS detector.

A measurement of the calorimeter response to isolated charged hadrons in the ATLAS detector at the LHC is presented. This measurement is performed with 3.2 nb[Formula: see text] of proton-proton collision data at [Formula: see text] [Formula: see text] from 2010 and 0.

H NMR To Evaluate the Metabolome of Bronchoalveolar Lavage Fluid (BALf) in Bronchiolitis Obliterans Syndrome (BOS): Toward the Development of a New Approach for Biomarker Identification.

This report describes the application of NMR spectroscopy to the profiling of metabolites in bronchoalveolar lavage fluid (BALf) of lung transplant recipients without bronchiolitis obliterans syndrome (BOS) (stable, S, n = 10), and with BOS at different degrees of severity (BOS 0p, n = 10; BOS I, n = 10). Through the fine-tuning of a number of parameters concerning both sample preparation/processing and variations of spectra acquisition modes, an efficient and reproducible protocol was designed for the screening of metabolites in a pulmonary fluid that should reflect the status of airway inflammation/injury. Exploiting the combination of mono- and bidimensional NMR experiments, 38 polar metabolites, including amino acids, Krebs cycle intermediates, mono- and disaccharides, nucleotides, and phospholipid precursors, were unequivocally identified.

Identification and rejection of pile-up jets at high pseudorapidity with the ATLAS detector.

The rejection of forward jets originating from additional proton-proton interactions (pile-up) is crucial for a variety of physics analyses at the LHC, including Standard Model measurements and searches for physics beyond the Standard Model. The identification of such jets is challenging due to the lack of track and vertex information in the pseudorapidity range . This paper presents a novel strategy for forward pile-up jet tagging that exploits jet shapes and topological jet correlations in pile-up interactions.

Study of and production in collisions at and search for anomalous quartic gauge couplings with the ATLAS experiment.

This paper presents a study of and triboson production using events from proton-proton collisions at a centre-of-mass energy of recorded with the ATLAS detector at the LHC and corresponding to an integrated luminosity of 20.2 fb . The production cross-section is determined using a final state containing an electron, a muon, a photon, and neutrinos ( ).

Measurement of production with the hadronically decaying boson reconstructed as one or two jets in collisions at with ATLAS, and constraints on anomalous gauge couplings.

This paper presents a study of the production of or boson pairs, with one boson decaying to or and one or boson decaying hadronically. The analysis uses of collision data, collected by the ATLAS detector at the Large Hadron Collider. Cross-sections for  /  production are measured in high- fiducial regions defined close to the experimental event selection.

Measurement of lepton differential distributions and the top quark mass in production in collisions at TeV with the ATLAS detector.

This paper presents single lepton and dilepton kinematic distributions measured in dileptonic events produced in 20.2 of  TeV collisions recorded by the ATLAS experiment at the LHC. Both absolute and normalised differential cross-sections are measured, using events with an opposite-charge pair and one or two -tagged jets.

Measurement of detector-corrected observables sensitive to the anomalous production of events with jets and large missing transverse momentum in collisions at TeV using the ATLAS detector.

Observables sensitive to the anomalous production of events containing hadronic jets and missing momentum in the plane transverse to the proton beams at the Large Hadron Collider are presented. The observables are defined as a ratio of cross sections, for events containing jets and large missing transverse momentum to events containing jets and a pair of charged leptons from the decay of a boson. This definition minimises experimental and theoretical systematic uncertainties in the measurements.

Determination of the strong coupling constant from transverse energy-energy correlations in multijet events at using the ATLAS detector.

Measurements of transverse energy-energy correlations and their associated asymmetries in multi-jet events using the ATLAS detector at the LHC are presented. The data used correspond to proton-proton collisions with an integrated luminosity of 20.2 .

Search for direct top squark pair production in final states with two leptons in TeV collisions with the ATLAS detector.

The results of a search for direct pair production of top squarks in events with two opposite-charge leptons (electrons or muons) are reported, using of integrated luminosity from proton-proton collisions at TeV collected by the ATLAS detector at the Large Hadron Collider. To cover a range of mass differences between the top squark and lighter supersymmetric particles, four possible decay modes of the top squark are targeted with dedicated selections: the decay into a -quark and the lightest chargino with , the decay into an on-shell top quark and the lightest neutralino, the three-body decay and the four-body decay . No significant excess of events is observed above the Standard Model background for any selection, and limits on top squarks are set as a function of the and masses.

Precision measurement and interpretation of inclusive , and production cross sections with the ATLAS detector.

High-precision measurements by the ATLAS Collaboration are presented of inclusive , and ( ) Drell-Yan production cross sections at the LHC. The data were collected in proton-proton collisions at with an integrated luminosity of . Differential and cross sections are measured in a lepton pseudorapidity range .

Measurement of jet fragmentation in Pb+Pb and collisions at TeV with the ATLAS detector at the LHC.

The distributions of transverse momentum and longitudinal momentum fraction of charged particles in jets are measured in Pb+Pb and collisions with the ATLAS detector at the LHC. The distributions are measured as a function of jet transverse momentum and rapidity. The analysis utilises an integrated luminosity of 0.

Measurement of the Inelastic Proton-Proton Cross Section at sqrt[s]=13 TeV with the ATLAS Detector at the LHC.

This Letter presents a measurement of the inelastic proton-proton cross section using 60  μb^{-1} of pp collisions at a center-of-mass energy sqrt[s] of 13 TeV with the ATLAS detector at the LHC. Inelastic interactions are selected using rings of plastic scintillators in the forward region (2.07<|η|<3.

World Health Organization disability assessment schedule 2.0: An international systematic review.

Purpose: This systematic review examines research and practical applications of the World Health Organization Disability Assessment Schedule (WHODAS 2.0) as a basis for establishing specific criteria for evaluating relevant international scientific literature. The aims were to establish the extent of international dissemination and use of WHODAS 2.

Search for Higgs and Z Boson Decays to ϕγ with the ATLAS Detector.

A search for the decays of the Higgs and Z bosons to a ϕ meson and a photon is performed with a pp collision data sample corresponding to an integrated luminosity of 2.7  fb^{-1} collected at sqrt[s]=13  TeV with the ATLAS detector at the LHC. No significant excess of events is observed above the background, and 95% confidence level upper limits on the branching fractions of the Higgs and Z boson decays to ϕγ of 1.

Ockham's razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer.

Background: Idiopathic pulmonary fibrosis (IPF) identifies a specific lung disorder characterized by chronic, progressive fibrosing interstitial pneumonia of unknown etiology, which lacks effective treatment. According to the current pathogenic perspective, the aberrant proliferative events in IPF resemble those occurring during malignant transformation.

Main Body: Receptor tyrosine kinases (RTK) are known to be key players in cancer onset and progression.

Comparison of Laparoscopic Microwave to Radiofrequency Ablation of Small Hepatocellular Carcinoma (≤3 cm).

Background: Laparoscopic thermal ablation is a common alternative to surgical resection in treating hepatic tumors, particularly in those located in difficult-to-reach locations.

Objective: The aim of this study was to compare the safety and long-term efficacy of laparoscopic radiofrequency ablation (RFA) and microwave ablation (MWA) in treating hepatocellular carcinoma (HCC).

Method: From February 2009 to May 2015, data from patients with HCC nodules who had undergone either laparoscopic MWA or laparoscopic RFA were examined.

Identification of miRNAs Potentially Involved in Bronchiolitis Obliterans Syndrome: A Computational Study.

The pathogenesis of Bronchiolitis Obliterans Syndrome (BOS), the main clinical phenotype of chronic lung allograft dysfunction, is poorly understood. Recent studies suggest that epigenetic regulation of microRNAs might play a role in its development. In this paper we present the application of a complex computational pipeline to perform enrichment analysis of miRNAs in pathways applied to the study of BOS.

Identification of boosted, hadronically decaying bosons and comparisons with ATLAS data taken at [Formula: see text] TeV.

This paper reports a detailed study of techniques for identifying boosted, hadronically decaying bosons using 20.3 fb[Formula: see text] of proton-proton collision data collected by the ATLAS detector at the LHC at a centre-of-mass energy [Formula: see text]. A range of techniques for optimising the signal jet mass resolution are combined with various jet substructure variables.

Sildenafil in severe pulmonary hypertension associated with chronic obstructive pulmonary disease: A randomized controlled multicenter clinical trial.

Background: Pulmonary hypertension (PH) is a well-known independent prognostic factor in chronic obstructive pulmonary disease (COPD) and a sufficient criterion for lung transplant candidacy. Limited data are currently available on the hemodynamic and clinical effect of phosphodiesterase 5 inhibitors in patients with severe PH associated with COPD. This study assessed the effect of sildenafil on pulmonary hemodynamics and gas exchange in severe PH associated with COPD.

Observation of Long-Range Elliptic Azimuthal Anisotropies in sqrt[s]=13 and 2.76 TeV pp Collisions with the ATLAS Detector.

ATLAS has measured two-particle correlations as a function of the relative azimuthal angle, Δϕ, and pseudorapidity, Δη, in sqrt[s]=13 and 2.76 TeV pp collisions at the LHC using charged particles measured in the pseudorapidity interval |η|<2.5.