Publications by authors named "Melody L Dong"
Article Synopsis
- Collateral arteries serve as natural bypasses that maintain blood flow during artery blockages, and enhancing their development could be a potential treatment for cardiac ischemia.
- Research using imaging and modeling on neonate and adult mouse hearts revealed that neonate collaterals are more effective at restoring blood flow compared to those in adults.
- In adults, the growth of coronary arteries involved adding branches rather than increasing size, leading to reduced effectiveness, highlighting the difference in collateral artery functionality between fetal and adult hearts and emphasizing their importance for heart regeneration and therapeutic strategies.
Background: Four-dimensional flow cardiovascular magnetic resonance imaging (4D flow CMR) allows comprehensive assessment of pulmonary artery (PA) flow dynamics. Few studies have characterized longitudinal changes in pulmonary flow dynamics and right ventricular (RV) recovery following a pulmonary endarterectomy (PEA) for patients with chronic thromboembolic pulmonary hypertension (CTEPH). This can provide novel insights of RV and PA dynamics during recovery.
View Article and Find Full Text PDFUntreated ventricular septal defects (VSDs) can lead to pulmonary arterial hypertension (PAH) characterized by elevated pulmonary artery (PA) pressure and vascular remodeling, known as PAH associated with congenital heart disease (PAH-CHD). Though previous studies have investigated hemodynamic effects on vascular mechanobiology in late-stage PAH, hemodynamics leading to PAH-CHD initiation have not been fully quantified. We hypothesize that abnormal hemodynamics from left-to-right shunting in early stage VSDs affects PA biomechanical properties leading to PAH initiation.
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