The implementation and effectiveness of Integrated Psychological Therapy (IPT) in chronic middle-aged inpatients with schizophrenia.

Introduction: Cognitive rehabilitation is essential for schizophrenia treatment since it improves function. Moreover, the relationship between cognitive rehabilitation and functioning is significantly affected by negative symptoms and social cognition. Integrated Psychological Therapy (IPT) is a promising approach that integrates interventions in neurocognition, social cognition, and functional level.

Correction: Professional Development of Behavior Analysts in Europe: A Snapshot for 21 Countries.

[This corrects the article DOI: 10.1007/s40617-022-00754-0.].

Professional Development of Behavior Analysts in Europe: A Snapshot for 21 Countries.

Behavior analysts are not recognized or regulated as a distinct profession in Europe. For the most part, European behavior analysts adhered to the standards set by the U.S.

Can We Panelize Seizure?

Seizure liability remains a significant cause of attrition in drug discovery and development, leading to loss of competitiveness, delays, and increased costs. Current detection methods rely on observations made in in vivo studies intended to support clinical trials, such as tremors or other abnormal movements. These signs could be missed or misinterpreted; thus, definitive confirmation of drug-induced seizure requires a follow-up electroencephalogram study.

Transitivity as Skinnerian problem solving controlled by self-constructed relational stimuli.

In tests of the derivation of complex relations such as transitivity, extant cues might fail to evoke effective responding, necessitating the construction of supplemental stimuli prior to their solution. The significance of this process was investigated by within-subject manipulation of an instructional variable designed to produce different levels of construction of supplemental stimulation concerning relationships among stimulus elements of concatenated conditional discriminations. In two experimental sessions, serial training of three 5-member stimulus classes occurred, either with the instruction to simply name the component stimuli or to both name them and generate a tale serially linking the stimuli named; such constructed stimuli might be spontaneously reconstructed by precurrent acts in subsequent tests of "emergent" relations.

Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular.

As the need for nasal, ocular, spinal, and articular therapeutic compounds increases, toxicology assessments of drugs administered via these routes play an important role in human safety. This symposium outlined the local and systemic evaluation to support safety during the development of these drugs in nonclinical models with some case studies. Discussions included selection of appropriate species for the intended route; conducting nonclinical studies that closely mimic the intended use with adequate duration; functional assessment, if deemed necessary; evaluation of local tissues with special histological staining procedure; and evaluations of safety margins based on local and systemic toxicity.

HESI/FDA workshop on immunomodulators and cancer risk assessment: Building blocks for a weight-of-evidence approach.

Profound immunosuppression (e.g., AIDS, transplant therapy) is epidemiologically associated with an increased cancer risk, and often with oncogenic viruses.

Exploring the relationship between posttraumatic growth, cognitive processing, psychological distress, and social constraints in a sample of breast cancer patients.

Posttraumatic growth (the perception of positive life changes after an encounter with a trauma) often occurs among breast cancer patients and can be influenced by certain demographic, medical, and psychosocial parameters. Social constraints on disclosure (the deprivation of the opportunity to express feelings and thoughts regarding the trauma) and the cognitive processing of the disease seem to be involved in the development of posttraumatic growth. Through the present study the authors aim to: investigate the levels of posttraumatic growth in a sample of 202 women with breast cancer in Greece, explore the relationships between posttraumatic growth and particular demographic, medical, and psychosocial variables according to a proposed model, and test the role of social constraints in the relationship between automatic and deliberate cognitive processing of the trauma.

Episodic Visual Learning/Memory and Attentional Flexibility in Patients With Major Depressive Disorder After Clinically Effective Electroconvulsive Therapy.

Objectives: This study is a follow-up of a previous one reporting that the neuropsychological profile of pharmacoresistant patients with major depressive disorder referred for electroconvulsive therapy (ECT, ECT group) contrasted with that of their pharmacorespondent counterparts (NECT group). The NECT group exhibited severe visuospatial memory and minor executive deficits; the ECT group presented the reverse pattern. In that same ECT group, the current follow-up study examined the effects of clinically effective ECT on both cognitive domains 2 months later.

Immunomodulation and lymphoma in humans.

Observational and clinical studies have associated increased cancer risks with primary or acquired immunodeficiencies, autoimmunity, and use of immunotherapies to treat chronic inflammation (e.g. autoimmunity) or support organ engraftment.

Psychological distress following wildfires disaster in a rural part of Greece: a case-control population-based study.

Psychological distress is common in the aftermath of a disaster. This study investigated psychological distress and morbidity in individuals who had experienced severe exposure to a wildfire disaster in a part of Greece. The study was a cross sectional case control of an adult population (18-65 years old).

Parental educational practices in relation to children's anxiety disorder-related behavior.

Schoolchildren reported their parents' use of aversive control and positive reinforcement contingencies in their educational interventions, as well as parental non-responsiveness to their requests for educational assistance. They also reported their own levels of six dimensions of anxiety disorder-related phenomena. Both parental use of aversive control and non-responsiveness were directly related to overall levels of child anxiety disorder-related behavior; these correlations were more robust than those observed in previous investigations of more diffuse dimensions of parenting style and trait anxiety.

Uniform assessment and ranking of opioid μ receptor binding constants for selected opioid drugs.

The safe disposal of unused opioid drugs is an area of regulatory concern. While toilet flushing is recommended for some drugs to prevent accidental exposure, there is a need for data that can support a more consistent disposal policy based on an assessment of relative risk. For drugs acting at the Mu-opioid receptor (MOR), published measurements of binding affinity (K(i)) are incomplete and inconsistent due to differences in methodology and assay system, leading to a wide range of values for the same drug thus precluding a simple and meaningful relative ranking of drug potency.

Compilation of international regulatory guidance documents for neuropathology assessment during nonclinical general toxicity and specialized neurotoxicity studies.

Neuropathology analyses as end points during nonclinical efficacy and toxicity studies are challenging and require trained personnel and particular equipment to achieve optimal results. Accordingly, many regulatory agencies have produced explicit guidelines for designing and performing neuropathology assessments for nonclinical studies. This compilation of international regulatory guidance for toxicologic neuropathology end points represents a set of criteria recommended for general toxicity studies and specialized neurotoxicity studies that should facilitate the efforts of individuals who plan, perform, analyze, and report neuropathology evaluations in nonclinical toxicity studies.

Continuing education course #3: current practices and future trends in neuropathology assessment for developmental neurotoxicity testing.

The continuing education course on Developmental Neurotoxicity Testing (DNT) was designed to communicate current practices for DNT neuropathology, describe promising innovations in quantitative analysis and noninvasive imaging, and facilitate a discussion among experienced neuropathologists and regulatory scientists regarding suitable DNT practices. Conventional DNT neuropathology endpoints are qualitative histopathology and morphometric endpoints of particularly vulnerable sites (e.g.

Superstitious perception: response-independent reinforcement and punishment as determinants of recurring eccentric interpretations.

This study provided controlled observations of a potential mechanism for the determination of the repetitive, aberrant perceptions or interpretations of everyday events that figure prominently in a range of psychological disorders: the adventitious reinforcement of acts of cognition by the actual consequences of concurrent motor acts. Adults made a series of two-choice brightness discriminations; on 60% of trials, choosing the brighter stimulus produced a "correct" signal while errors produced an aversive sound. On 40% of trials, the choice stimuli did not in fact differ in brightness; the consequences of responding on these "identical stimuli" trials differed across blocks of trials.

Locus of control and psychopathology in relation to levels of trauma and loss: self-reports of Peloponnesian wildfire survivors.

This study investigated whether relations between beliefs about the personal controllability of reinforcing events and levels of psychopathology were differentiated with respect to levels of trauma and loss experienced in a series of devastating wildfires. In contrast with studies of combat veterans and professional firefighters, in wildfire survivors external locus of control beliefs and psychopathology were correlated only in respondents who experienced higher levels of trauma and loss; specifically, for residents of designated disaster areas (N = 409), but not for a demographically matched sample of residents of adjacent, non-fire-damaged areas (N = 391). The conflicting findings across studies are interpreted with respect to probable differences in contingencies of reinforcement for causal attributions in professionals and in novices in disaster management.

Identification of recycled water with an empirically derived symbol increases its probability of use.

The experiment described in this paper compared the effects of two systems for labeling recycled water on potential consumers' intention to use this resource; the current identifying symbol used worldwide (purple color for pipes, containers, and tanks) and a new, empirically derived and validated set of symbols that provide specific information on water quality and positive comparative information. In total, 807 face-to-face surveys were carried out. Subjects were asked to rate their intentions for using different qualities of recycled water for commercial agriculture as well as for using products and facilities irrigated with recycled water, either in the presence of the established symbol or the new, empirically derived symbols.

Use of anesthetic agents in neonates and young children.

Background: Some drugs used for sedation and anesthesia produce histopathologic central nervous system changes in juvenile animal models. These observations have raised concerns regarding the use of these drugs in pediatric patients. We summarized the findings in developing animals and describe the steps that the Food and Drug Administration (FDA) and others are taking to assess potential risks in pediatric patients.

Structure, developmental course, and correlates of children's anxiety disorder-related behavior in a Hellenic community sample.

The generality of the DSM-IV diagnostic structure for children's anxiety disorders, as measured by the Spence Children's Anxiety Scale (SCAS) was investigated with a Greek-language version of the scale. An exploratory factor analysis produced a six-factor solution in general accord with the DSM-IV-based theoretical structure of responding. However, a generalized anxiety factor incorporated three unexpected items interpreted as representing excessive worry, including two items intended to measure obsessions, raising the question of children's ability to discriminate the intrusiveness of vexatious cognition.

Normative development of fears in Greece: self-reports on the Hellenic Fear Survey Schedule for Children.

This study assessed the psychometric properties of self-reports on the Hellenic Fear Survey Schedule for Children (FSSC-GR), a Greek-language version of Ollendick's FSSC-R [Behav. Res. Ther.

Regulatory effects of deoxycholic acid, a component of the anti-inflammatory traditional Chinese medicine Niuhuang, on human leukocyte response to chemoattractants.

Niuhuang is a commonly used Chinese traditional medicine with immunoregulatory and anti-inflammatory properties. Deoxycholic acid (DCA) is a major active constituent of Niuhuang. The reaction of human leukocytes to chemoattractants is an important part of the host immune response and also plays a crucial role in the development of inflammation.