Publications by authors named "Melkane A"

Background: The CO laser is frequently used during microlaryngeal surgery (MLS) for a variety of pathology including laryngeal malignancy and stenosis. Learning how to use the laser safely is part of the curriculum for every otolaryngology resident. However, assessment of laryngoscopy technical skills can be challenging for supervisors, making it difficult to adequately provide feedback to trainees.

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Cervical sympathetic chain schwannomas are uncommon benign tumors that usually develop in the retrostyloid compartment of the parapharyngeal space. Differentiating cervical sympathetic chain schwannomas from other lesions of the retrostyloid parapharyngeal space can be very difficult. We present a case of a major ingrowth of a cervical lesion, covering the larynx and obstructing the airway beyond the midline.

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Purpose: With recent advances in artificial intelligence (AI), it has become crucial to thoroughly evaluate its applicability in healthcare. This study aimed to assess the accuracy of ChatGPT in diagnosing ear, nose, and throat (ENT) pathology, and comparing its performance to that of medical experts.

Methods: We conducted a cross-sectional comparative study where 32 ENT cases were presented to ChatGPT 3.

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 Oral cavity squamous cell carcinoma (OCSCC) is the most common malignancy in the oral cavity. Two types of mandibular resections have been described: the segmental mandibulectomy and the marginal mandibulectomy. Both may have a different impact over the quality of life, oncological prognosis, and functional or aesthetic result.

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Background: To analyze worldwide practices regarding the initiation of oral feeding after total laryngectomy (TL).

Methods: Online survey.

Results: Among the 332 responses received, 278 from 59 countries were analyzed.

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Objectives: Forestier's disease or diffuse idiopathic skeletal hyperostosis (DISH) is a common, yet underreported, disease affecting the elderly population. From an otolaryngologic perspective, DISH may manifest with dysphagia, dysphonia, or even dyspnea. The purpose of this study was to identify all published cases of dysphagia and other associated upper airway symptoms resulting from DISH in the last decade and to establish subsequently a management algorithm.

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Article Synopsis
  • This study explored the safety and effectiveness of transoral robotic surgery (TORS) for reducing the base of the tongue in patients with obstructive sleep apnea (OSAS), analyzing data from PubMed, Cochrane Library, and Scopus.
  • A meta-analysis of 31 cohorts consisting of 1,693 patients found that TORS significantly reduced the Apnea-Hypopnea Index (AHI) by an average of 24.25 events per hour and improved the Epworth Sleepiness Scale (ESS) by nearly 8 points.
  • The success rate for TORS in reducing base of tongue size was reported at 69%, indicating it may be a safe and effective option for improving breathing and sleep quality in these patients
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Aims: To evaluate the effectiveness of a brief smoking cessation intervention in head and neck cancer patients (HNCP).

Study Design: A prospective randomized controlled trial that randomly assigns participants in two groups: a usual care group (UCG), and a standardized intervention group (SIG).

Material And Methods: Patients with a confirmed diagnosis of head and neck squamous cell carcinoma (HNSCC) and who are active smokers were prospectively approached by one of 4 trained Ear-nose-throat (ENT) residents.

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Adult-type rhabdomyoma (ARM) is the most frequent extracardiac subtype of rhabdomyoma. In very rare instances ARM presents as multiple cervical lesions, an entity known as multifocal ARM. The aim of this study was to review the clinical characteristics and the best therapeutic options for multifocal ARM.

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Background: It has become clear that healthcare workers are at high risk, and otolaryngology has been theorized to be among the highest risk specialties for coronavirus disease 2019 (COVID-19). The purpose of this study was to detail the international impact of COVID-19 among otolaryngologists, and to identify instructional cases.

Methods: Country representatives of the Young Otolaryngologists-International Federation of Otolaryngologic Societies (YO-IFOS) surveyed otolaryngologists through various channels.

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Background: The aim of this systematic review is to shed light the current indications and outcomes of transoral robotic surgery (TORS) supraglottic laryngectomy (SGL) in patients with supraglottic laryngeal cancer.

Methods: PubMed, Scopus and Cochrane Library were searched by three independent otolaryngologists from the Young Otolaryngologists of IFOS for studies investigating the indications, effectiveness and safety of TORS SGL. Surgical, functional, and survival outcomes have been investigated.

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Background: Surgical site infection (SSI) is defined as an infection that occurs after a surgical incision or organ manipulation during surgery. The frequency reported for clean head and neck surgical procedures without antimicrobial prophylaxis is <1%. In contrast, infection rates in patients undergoing complicated cancer surgery are high, ranging from 24% to 87% of patients without antimicrobial prophylaxis.

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Objectives: To document the challenges faced by residents in Otolaryngology - Head & Neck Surgery (OTL-HNS) around the world to successfully complete research projects. The second objective is to assess if the challenges are uniform worldwide.

Methods: A survey was sent to all OTL-HNS under 45 years old from the 2017 IFOS meeting.

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Objectives: To evaluate for the first time the prevalence of human papillomavirus in oropharyngeal squamous cell carcinoma in a Middle-Eastern population, and to determine associations between human papillomavirus profiles and clinicopathological characteristics.

Methods: A retrospective chart review was conducted of all patients treated for oropharyngeal squamous cell carcinoma at the Hotel Dieu de France University Hospital (Beirut, Lebanon) between January 2010 and 2016. Existing formalin-fixed paraffin-embedded tumour samples were analysed.

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Objectives: Evaluate the reliability of sentinel node biopsy (SNB) in T1/T2 cN0 oral squamous cell carcinoma (OSCC), and compare recurrence-free time (RFT) and overall survival (OS) between patients undergoing SNB and neck dissection (ND).

Patients And Methods: Patients with T1/T2 cN0 OSCC underwent SNB followed by systematic ND in the first cohort and SNB followed by selective ND in case of positive sentinel nodes (SN) in the second cohort.

Results: A total of 229 patients were followed (first cohort 50, second cohort 179).

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Background: Accurate identification of HPV-driven oropharyngeal cancer (OPC) is a major issue and none of the current diagnostic approaches is ideal. An in situ hybridization (ISH) assay that detects high-risk HPV E6/E7 mRNA, called the RNAscope HPV-test, has been recently developed. Studies have suggested that this assay may become a standard to define HPV-status.

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Objectives/hypothesis: To contrast the changes in measurement of the hypoglossal/lingual artery neurovascular bundle (HLNVB) to constant surface landmarks in the base of tongue (BOT) during surgically simulated retraction versus resting anatomic position, and to identify a safe zone for BOT robotic surgery to avoid injury to the HLNVB.

Study Design: Human cadaver study.

Methods: Five fresh-frozen head and neck complexes were obtained, and seven HLNVBs were dissected.

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Background: Lymphatic vessel density (LVD) has been shown to be an important predictor of survival in head and neck cancers. We report the predictive value of LVD for progression-free survival (PFS) and overall survival (OS) in laryngeal/hypopharyngeal cancer.

Methods: Fifty-five untreated patients with T3/T4 laryngeal and T4 hypopharyngeal cancer underwent laryngectomy between 1999 and 2010.

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Article Synopsis
  • The study examined the presence and impact of MET genetic alterations in oropharyngeal squamous cell carcinoma (OPSCC) to evaluate potential targeted therapies.
  • Only 4% of the 143 patients showed any MET genetic variation, with some known mutations absent and limited true MET amplification cases identified.
  • Overall, the findings indicated no significant link between MET changes and patient survival, suggesting that using MET abnormalities for treatment decisions in OPSCC may not be effective.
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High risk Human Papilloma virus (HR-HPV) associated oropharyngeal cancers are on the increase. Although, the scientific community is aware of the importance of Human Papilloma Virus (HPV) testing, there is no consensus on the assays that are required to reliably identify HR-HPV related tumors. A wide range of methods have been developed.

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Purpose: HPV-related oropharyngeal squamous cell carcinomas clearly represent a growing entity in the head and neck with distinct carcinogenesis, clinico-pathological presentation and survival profile. We aimed to compare the HPV prevalence rates and clinico-pathological correlations obtained with three distinct commonly used HPV detection methods.

Materials And Methods: p16-immunohistochemistry (IHC), HPV DNA viral load by real-time PCR (qPCR), and HPV genotyping by a reverse hybridization-based line probe assay (INNO-LiPA) were performed on pretreatment formalin-fixed paraffin-embedded tumor samples from 46 patients treated for single primary oropharyngeal carcinomas.

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Background: Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) is associated with favorable survival. The purpose of this study was to evaluate the prevalence and prognostic significance of the HPV infection through both the p16 expression status and the oncogenic HPV DNA viral load.

Methods: A retrospective chart review was conducted on all patients treated for oropharyngeal SCC between January 2007 and June 2009.

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Objectives/hypothesis: To evaluate the reliability of the sentinel node (SN) biopsy in early oral squamous cell carcinomas.

Study Design: Prospective cohort study.

Methods: We conducted a primary prospective study on 53 consecutive patients presenting T1, T2 N0 squamous cell carcinomas of the oral cavity between January 2000 and June 2003.

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