Publications by authors named "Meliza da Conceicao Oliveira"
Mechanisms involved in the antidepressant-like action of orally administered 5-((4-methoxyphenyl)thio)benzo[c][1,2,5]thiadiazole (MTDZ) in male and female mice.
Karline da Costa Rodrigues Meliza da Conceição Oliveira Beatriz Fuzinato Dos Santos Nelson Luís de Campos Domingues Mariana Gallio Fronza
Psychopharmacology (Berl)
November 2024
Rationale: The compound 5-((4-methoxyphenyl)thio)benzo[c][1,2,5]thiadiazole (MTDZ) has recently been shown to inhibit in vitro acetylcholinesterase activity, reduce cognitive damage, and improve neuropsychic behavior in mice, making it a promising molecule to treat depression.
Objectives: This study investigated the antidepressant-like action of MTDZ in mice and its potential mechanisms of action.
Results: Molecular docking assays were performed and suggested a potential inhibition of monoamine oxidase A (MAO-A) by MTDZ.
Curcumin and Quercetin-Loaded Lipid Nanocarriers: Development of Omega-3 Mucoadhesive Nanoemulsions for Intranasal Administration.
Gustavo Richter Vaz Mariana Corrêa Falkembach Carrasco Matheus Monteiro Batista Paula Alice Bezerra Barros Meliza da Conceição Oliveira Patrícia Diaz de Oliveira
Nanomaterials (Basel)
March 2022
Article Synopsis
- - Curcumin (CUR) and quercetin (QU) show promise in treating neurodegenerative diseases due to their anti-inflammatory and antioxidant properties, but their effectiveness is limited by low water solubility and poor bioavailability.
- - This study explores the use of omega-3 fatty acid nanoemulsions (NEs) loaded with CUR and QU, prepared via two methods for intranasal administration, revealing that both methods produced stable formulations but showed differences in size and release characteristics.
- - High-pressure homogenization (HPH) was identified as the superior method, resulting in a nanoemulsion that demonstrated potential for sustained release of the compounds, while toxicity tests indicated that the formulations were not harmful, suggesting improved delivery for