A novel insight into neurological disorders through HDAC6 protein-protein interactions.

Due to its involvement in physiological and pathological processes, histone deacetylase 6 (HDAC6) is considered a promising pharmaceutical target for several neurological manifestations. However, the exact regulatory role of HDAC6 in the central nervous system (CNS) is still not fully understood. Hence, using a semi-automated literature screening technique, we systematically collected HDAC6-protein interactions that are experimentally validated and reported in the CNS.

Finding Joy and Purpose Through Singing: Giving Voice to People Living With Dementia.

For every individual living with dementia, the experience is unique. When you meet one person living with dementia, you have simply met one person. Dementia will change many things about life-but not all at once and often over many years.

Prepared to Respond? Exploring Personal Disaster Preparedness and Nursing Staff Response to Disasters.

Objectives: This pilot study explored personal disaster preparedness of nursing staff and their ability and willingness to respond following a disaster.

Methods: All nurses from a single hospital were invited to participate; 91 completed an online survey asking them to rate their ability and willingness to report to work following the disaster scenarios and to indicate whether they had pursued various preparedness activities. Data were analyzed by descriptive and inferential statistics using Minitab 17 Statistical Software.

Identification of Biological Pathways Contributing to Marbling in Skeletal Muscle to Improve Beef Cattle Breeding.

Red meat is an important dietary source that provides part of the nutritional requirements. Intramuscular fat, known as marbling, is located throughout skeletal muscle. Marbling is a trait of major economic relevance that positively influences sensory quality aspects.

Consideration of Factors Influencing Weight Outcomes among U.S. Racial-Ethnic Minority Populations in the Social Work Literature.

Objective: This study explores the social work profession's empirical contribution to addressing factors influencing overweight and obesity outcomes among racial-ethnic minority populations in the United States. The high prevalence of obesity in U.S.

WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research.

WikiPathways (wikipathways.org) captures the collective knowledge represented in biological pathways. By providing a database in a curated, machine readable way, omics data analysis and visualization is enabled.

A comparative assessment of major international disasters: the need for exposure assessment, systematic emergency preparedness, and lifetime health care.

Background: The disasters at Seveso, Three Mile Island, Bhopal, Chernobyl, the World Trade Center (WTC) and Fukushima had historic health and economic sequelae for large populations of workers, responders and community members.

Methods: Comparative data from these events were collected to derive indications for future preparedness. Information from the primary sources and a literature review addressed: i) exposure assessment; ii) exposed populations; iii) health surveillance; iv) follow-up and research outputs; v) observed physical and mental health effects; vi) treatment and benefits; and vii) outreach activities.

Exploring U.S. Hispanic parents' length of time in the United States: Influences on obesity outcomes among U.S. Hispanic children.

The 2009 California Health Interview Survey was used to examine effects of Hispanic immigrant parents' length of stay (less or more than 10 years) in the United States on the overweight and obesity outcomes among their children (N = 956, aged 6-11). The socio-ecological model of health was used to conceptualize health risk behaviors and associations with overweight/obesity outcomes among children. Weight (using body mass index) among children was influenced by parents' length of stay, country of origin, income, and urban/rural residence.

WikiPathways: capturing the full diversity of pathway knowledge.

WikiPathways (http://www.wikipathways.org) is an open, collaborative platform for capturing and disseminating models of biological pathways for data visualization and analysis.

Occupational safety and health protections against Ebola virus disease.

Even as the Ebola epidemic is finally showing signs of remitting, controversy continues regarding the modes of disease transmission, the understanding of which necessarily dictates methods of prevention. The initial public health response to the epidemic was based on assumptions formed during previous outbreaks, and in the belief that transmission was restricted to direct "contact" with other infected patients. However, the current Ebola outbreak differed from previous experiences in its intensity of transmission, speed of spread, and fatality rate and was also particularly unforgiving on health workers occupationally infected.

Exploring social workers' use of the socioecological model as an intervention and research framework for treating overweight or obese clients.

The purpose of this study was to identify the empirical contribution made by the social work profession in the prevention and treatment of overweight and obesity. The constructs of the socioecological model of health, which suggest that there are multiple levels of influence on individual behaviors, were used as a conceptual framework to synthesize studies authored by social work researchers investigating overweight and obesity risk factors. A review of obesity-related research written by social workers published over an unrestricted time was conducted.

Overweight and obesity in minority children and implications for family and community social work.

The 2007 California Health Interview Survey was used to examine indicators of overweight and obesity among racial and ethnic minority children age 2 to 11 (N = 6,669). The factors found to most influence overweight/obesity were race/ethnicity, poverty level, and physical activity. Neighborhood access to a park or playground within walking distance reduced the odds of overweight and obesity despite control for other factors.

Asphalt--a continuing challenge.

Assessing the health risks of complex mixtures of polynuclear aromatic hydrocarbons such as diesel fumes and asphalt or bitumen continues to be a major challenge for occupational and environmental health scientists. The special Asphalt issue of the American Journal of Industrial Medicine (Cancer Mortality Among European Asphalt Workers (Am.J.

Development of a medical examination program for former workers at a Department of Energy national laboratory.

Background: As a part of the U.S. Department of Energy (DOE) Former Workers' Medical Surveillance Program, a Needs Assessment was conducted at Los Alamos National Laboratory (LANL).

Occupational health for firefighters.

Occupational health and safety programs for firefighters have received increasing attention over the last several years, due to the growing recognition of potential long-term health risks for firefighters. These workers not only face severe physical and psychological demands, but also risks of chronic or delayed adverse job-related health consequences. Firefighters are routinely exposed to a large number of toxic substances (e.

Design and conduct of occupational injury intervention studies: a review of evaluation strategies.

Occupational injuries continue to exact a great toll on American workers and their employers--the physical and financial costs are enormous. However, in the current political climate, few employers or regulatory agencies will implement injury prevention interventions without specific evidence of their effectiveness. This paper reviews the literature on the design, conduct, and evaluation of occupational injury interventions.

Stress among package truck drivers.

In 1992, a cross-sectional questionnaire study of package truck drivers in one company was conducted at four widely scattered sites throughout the US; 317 drivers participated, representing 82% of those eligible. The package truck drivers scored significantly above the US working population comparison norm on all summary and individual scales derived from the SCL 90-R, indicating a substantial increase in psychologic distress for this group. The Global Severity Index, the best single summary measure of psychological distress in the SCL 90-R, revealed a mean T score for the drivers of 64.

Breast cancer risk and residence near industry or traffic in Nassau and Suffolk Counties, Long Island, New York.

A case-control interview study was used to evaluate the relationship between breast cancer risk and residential proximity to industrial facilities and traffic for pre- and postmenopausal women in Nassau and Suffolk Counties on Long Island, New York. A geographic information system was used to assign industry and traffic counts to 1-km2 grid cells (5-kM2 grid cells for traffic) and to assign potential exposure values to study subjects, based on 20-y residential histories. A significantly elevated risk of breast cancer was observed among postmenopausal subjects who were ever potentially exposed to chemical facilities (Nassau County adjusted odds ratio [OR] = 1.

Cardiovascular disease among firefighters.

The author reviews the literature of the past 20 years on heart disease among firefighters, covering the specific aspects of firefighting that may be related to potential cardiovascular disease. The author then outlines steps that can be taken to reduce the risks of developing cardiovascular disease.

Health insurance and workers' compensation: the delivery of medical and rehabilitation services for construction workers.

The construction industry has one of the highest proportions of workers without health insurance. The authors review the two types of insurance systems that are generally used to cover the cost of health care for construction workers in the U.S.

Lead poisoning in construction.

Ways to prevent lead poisoning and regulations intended to eliminate exposures to lead are the topics here. Lead registries and other studies are described that were designed to evaluate the extent of the problem and to address the lack of routine blood-lead monitoring in the industry.