Publications by authors named "Melissa Yaroschak"
Article Synopsis
- Researchers synthesized five new metal complexes using specific ligands (L1, L2, L3) involving metal ions cadmium (Cd(II)) and mercury (Hg(II)).
- X-ray crystallography showed these complexes have a consistent octahedral structure with N8 coordination, and bond distances varied based on the type of nitrogen in the ligands.
- (1)H NMR spectroscopy indicated that the Cd(II) complexes had a greater tendency for slow intramolecular changes compared to the Hg(II) complexes, revealing interesting interactions between the ligands and metal ions.
This article describes recent advances in the development and biological evaluation of small molecule inhibitors for the serine/threonine kinase Akt (PKB). Akt plays a pivotal role in cell survival and proliferation through a number of downstream effectors. Recent studies indicate that unregulated activation of the PI3K/Akt pathway is a prominent feature of many human cancers and Akt is over-expressed or activated in all major cancers.
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