Publications by authors named "Melissa Weldy"
Background: Fecal microbiota transplants can be administered orally in encapsulated form or require invasive procedures to administer liquid formulations. There is a need for an oral liquid formulation of fecal microbiota for patients who are unable to swallow capsules, especially if they require multiple, repeated administrations.
Aims: These studies were conducted to develop a protocol to manufacture an organoleptically acceptable powdered fecal microbiota formulation that can be suspended in a liquid carrier and used for fecal microbiota transplantation.
Article Synopsis
- * Adding a sulfate group to bile acids can lower their absorption and increase the amount excreted in feces, making them better for targeting the gut.
- * For IBD treatment, a different strategy is used where a 7-methoxy group increases potency at the TGR5 receptor, and a methyl-d-glucamine group is added to balance receptor activity with low absorption and good fecal recovery.
, an obligate anaerobic bacterium, causes infections leading to prolonged diarrhea. The bacterium produces dormant spores that can withstand an aerobic environment, resulting in easy environmental transfer. Here, we present a convenient sporulation and purification protocol that can be practiced in any lab setting using a portable anaerobic glove bag.
View Article and Find Full Text PDFcauses nearly 500,000 infections and nearly 30,000 deaths each year in the U.S., which is estimated to cost $4.
View Article and Find Full Text PDF