Synthesis and Evaluation of Marine-Inspired Compounds Result in Hybrids with Antitrypanosomal and Antileishmanial Activities.

Natural products are a very rich source for obtaining new compounds with therapeutic potential. In the search for new antiparasitic and antimicrobial agents, molecular hybrids were designed based on the structures of antimicrobial marine quinazolinones and eugenol, a natural phenolic compound. Following reports of the therapeutic potential of quinazolinones and eugenol derivatives, it was expected that the union of these pharmacophores could generate biologically relevant substances.

New Antifungal Agents with Azole Moieties.

Fungal conditions affect a multitude of people worldwide, leading to increased hospitalization and mortality rates, and the need for novel antifungals is emerging with the rise of resistance and immunocompromised patients. Continuous use of azole drugs, which act by inhibiting the fungal CYP51, involved in the synthesis of ergosterol, essential to the fungal cell membrane, has enhanced the resistance and tolerance of some fungal strains to treatment, thereby limiting the arsenal of available drugs. The goal of this review is to gather literature information on new promising azole developments in clinical trials, with in vitro and in vivo results against fungal strains, and complementary assays, such as toxicity, susceptibility assays, docking studies, among others.

Contributions of activity ergonomics to the design of an electronic health record to support collaborative mental care of children and youth: Preliminary results.

Background: The use of electronic health records (EHR) is related to the improvement of service quality and care coordination. The design of this platform generally focuses on the individual use of the system and does not integrate the specific needs of workers to provide support for collaborative activities.

Objective: The study investigated how activity ergonomics (AE) contributed to improve the design of an EHR that supports the collaborative mental health care of children and youth.

Atlantic butterflies: a data set of fruit-feeding butterfly communities from the Atlantic forests.

Butterflies are one of the best-known insect groups, and they have been the subject of numerous studies in ecology and evolution, especially in the tropics. Much attention has been given to the fruit-feeding butterfly guild in biodiversity conservation studies, due to the relative ease with which taxa may be identified and specimens sampled using bait traps. However, there remain many uncertainties about the macroecological and biogeographical patterns of butterflies in tropical ecosystems.

Primary care and collaborative care in children and adolescents psychosocial interventions: facilitators and barriers.

Considering the care gap in child and youth psychosocial care, the articulation of the intra-sectoral network is an important strategy to promote less fragmented care flows. The study analyzes facilitators and obstacles to collaborative care between the Family Health Strategy (ESF) and a Child and Youth Psychosocial Care Center (CAPSi) in Rio de Janeiro/RJ. This is an exploratory study with a qualitative approach, which main methodological tools were focus and intervention groups.