Sex differences in aggressive intensities and brain steroids during status resolution in a sex changing fish, Lythrypnus dalli.

For vertebrates living in social hierarchies, the neuroendocrine system regulates temporal aspects of aggressive interactions during status establishment. In teleost fishes, the sex steroids 17β-estradiol (E) and 11-ketotestosterone (KT), and the glucocorticoid, cortisol (CORT) are associated with aggression in distinct phases of their life history. Bluebanded gobies, Lythrypnus dalli, exhibit bidirectional sexual plasticity by responding to changes in their social structure by escalating aggression associated with neural changes that precede gonadal reorganization to the opposite sex.

Cigarette smoke induction of S100A9 contributes to chronic obstructive pulmonary disease.

S100 calcium-binding protein A9 (S100A9) is elevated in plasma and bronchoalveolar lavage fluid (BALF) of patients with chronic obstructive pulmonary disease (COPD), and aging enhances S100A9 expression in several tissues. Currently, the direct impact of S100A9-mediated signaling on lung function and within the aging lung is unknown. Here, we observed that elevated S100A9 levels in human BALF correlated with age.

Airway Resistance Caused by Sphingomyelin Synthase 2 Insufficiency in Response to Cigarette Smoke.

Sphingomyelin synthase is responsible for the production of sphingomyelin (SGM), the second most abundant phospholipid in mammalian plasma, from ceramide, a major sphingolipid. Knowledge of the effects of cigarette smoke on SGM production is limited. In the present study, we examined the effect of chronic cigarette smoke on sphingomyelin synthase (SGMS) activity and evaluated how the deficiency of , one of the two isoforms of mammalian SGMS, impacts pulmonary function.