Publications by authors named "Melissa Queen"
The ability to sequence single protein molecules in their native, full-length form would enable a more comprehensive understanding of proteomic diversity. Current technologies, however, are limited in achieving this goal. Here, we establish a method for the long-range, single-molecule reading of intact protein strands on a commercial nanopore sensor array.
View Article and Find Full Text PDFAs global demand for digital storage capacity grows, storage technologies based on synthetic DNA have emerged as a dense and durable alternative to traditional media. Existing approaches leverage robust error correcting codes and precise molecular mechanisms to reliably retrieve specific files from large databases. Typically, files are retrieved using a pre-specified key, analogous to a filename.
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- Molecular tagging uses DNA or other molecules to label objects when traditional methods like RFID tags and QR codes aren't suitable.
- Porcupine is a fast, portable system that reads DNA-based tags quickly with a nanopore device, using the presence or absence of unique DNA strands to represent digital information (molecular bits or molbits).
- It enhances tag durability and readout efficiency by preparing and dehydrating molbits during assembly, leading to a high-accuracy, extensible tagging system capable of creating distinct barcodes.