Publications by authors named "Melissa Perfranceschi"
The devastating COVID-19 outbreak posed serious challenges for the diagnostics laboratories, facing global shortage of reagents and equipment. This study aimed at evaluating an additional RNA extraction method respect to those already recommended by WHO and CDC. A new protocol for RNA extraction from nasopharyngeal swab was set up, adapting a Qiagen kit, and validated on a set of 96 clinical samples.
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- This study explored the diagnostic potential of specific serum microRNAs (miRNAs) associated with endometrial carcinoma (EC), a common gynecological cancer.
- Researchers analyzed serum samples from 46 women with EC and 28 healthy controls, focusing on the expression levels of four miRNAs: miR-222, miR-223, miR-186, and miR-204.
- The results indicated that miR-186, miR-222, and miR-223 were significantly higher in EC patients, while miR-204 was lower, suggesting these miRNAs could serve as more effective biomarkers for EC compared to traditional markers like CA125.