Publications by authors named "Melissa Mayo"
Article Synopsis
- mRNA therapies have become popular, especially after the approval of mRNA vaccines against SARS-CoV-2, but large-scale production faces significant challenges.
- The production process can be inefficient and costly due to issues with incorporating necessary cap analogs and the creation of unwanted double-stranded RNA byproducts that can trigger immune reactions.
- Researchers have developed a new RNA polymerase called T7-68 that improves the incorporation of cap analogs and reduces the presence of harmful dsRNA, enhancing the efficiency of mRNA production.
Background: Obesity around the world is increasing at an alarming rate. One of the issues with obesity is whether exercise with large energy expenditure have any effect on obesity risk factors such as insulin resistance and coronary heart diseases.
Methods: Twenty participants (mean age: 19.
Blueprints for the rational design of therapeutic mutacin 1140 variants.
Chem Biol Drug Des
December 2018
Lantibiotics represent a large untapped pipeline of attractive scaffolds for the development of novel antibiotics. Saturation mutagenesis was employed to substitute every amino acid of a lantibiotic called mutacin 1140 (MU1140), creating an unbiased expression library of 418 variants that was used to study the permissiveness to mutagenesis and the "drugability" of several compounds. Contrasting previous reports, the results from this study supported that not all residues involved in lanthionine bridge formation were critical for maintaining optimal activity.
View Article and Find Full Text PDFExercise-induced weight loss preferentially reduces abdominal fat.
Med Sci Sports Exerc
February 2003
Purpose: To investigate whether abdominal fat is reduced in response to substantial weight loss induced by exercise in young obese men.
Methods: Thirty obese men (mean age 19.8 +/- 0.