Distinct NSCLC Variants in a Family With Li-Fraumeni Syndrome: Case Report.

Introduction: Heritable lung cancer may occur in the context of germline mutations (Li-Fraumeni syndrome). Limited cases of intrafamily tumor genomic characteristics have been reported.

Main Concerns Important Clinical Findings Primary Diagnoses interventions Outcomes: A 40-year-old woman with no smoking history or known environmental exposure risk was incidentally found to have stage II (T2N1) NSCLC harboring an exon 19 p.

Systemic and Intracranial Efficacy of Osimertinib in L747P-Mutant NSCLC: Case Report.

Introduction: L747P mutations occur rarely, with limited preclinical research and case reports suggesting resistance to osimertinib.

Main Concerns Important Clinical Findings Primary Diagnoses Interventions Outcomes: An 84-year-old white male with remote smoking history presented with bilateral pulmonary nodules and multiple subcentimeter enhancing brain lesions 2 years after receiving stereotactic radiation therapy for a left upper lobe lung adenocarcinoma. After two computed tomography-guided biopsies yielded inadequate tissue and cell-free DNA analysis identified no actionable alterations, surgical biopsy results revealed an L747P mutation.

Histologic transformation of EGFR mutant lung adenocarcinoma without exposure to EGFR inhibition.

Resistance to EGFR kinase inhibitors appears to be invariable in the treatment of non-small cell lung cancer. Several mechanisms have been described. Here, we report the first case of histologic transformation of EGFR mutant lung adenocarcinoma without prior exposure to EGFR inhibition.

Upper lip metastasis of sarcomatoid carcinoma of the lung - an unusual site of disease: a case report.

Background: Lip metastases are rare clinical events that are frequently mistaken for other diagnoses. For sarcomatoid lung carcinoma, a rare histologic variant of non-small cell lung cancer, the incidence and pattern of cutaneous spread is poorly understood.

Case Presentation: We present a case of a 79-year-old African American man with a rapidly progressive upper lip cutaneous lesion that provided the first evidence of distant metastatic spread of sarcomatoid lung carcinoma.

"They're Doing Something That Actually No One Else Can Do": A Qualitative Study of Peer Support and Primary Care Integration.

Peer support (PS) is a strategy for improving quality of care for people with chronic disease and is increasingly being integrated with primary care. We conducted semistructured qualitative interviews with 18 staff members from 4 practices that have integrated PS and primary care. From these interviews, we identified several benefits of PS and primary care integration as well as challenges to integrating and sustaining PS programs.

Effects of a Presidential Candidate's Comments on HPV Vaccine.

During and after the 2011 Republican presidential debate, a candidate questioned the safety of HPV vaccine. The authors aimed to determine the effect of these comments on parents. A national sample of 327 parents with adolescent sons ages 11-17 years completed online surveys in fall 2010 (baseline, about 1 year before the debate) and 2011 (follow-up, about 1 month after the debate).

Emotional support for diabetes management: an international cross-cultural study.

Purpose: The purpose of this study was to explore how emotional support emerged in interactions between peer supporters (PSs) and adults living with type 2 diabetes.

Methods: Qualitative data were analyzed from 22 semistructured interviews with PSs in 3 settings: low-income Latinos in Chicago, middle-class Caucasians in the United Kingdom, and low-income African American women in North Carolina. Emotional support was defined as expressions of empathy, trust, and caring.

Parents' and sons' beliefs in sexual disinhibition after human papillomavirus vaccination.

Background: The concern that adolescent girls who receive human papillomavirus (HPV) vaccine may be more likely to have sex (ie, sexual disinhibition) has been commonplace in media coverage, but this belief is not held by many parents of adolescent girls. Because no studies have addressed this topic for adolescent boys, we examined parents' and their adolescent sons' beliefs in sexual disinhibition occurring after boys receive HPV vaccine.

Methods: A national sample of parents of adolescent boys (n = 547) and their sons (aged 15-17 years; n = 176) completed online surveys in fall 2010.

Development and validation of the smoking abstinence expectancies questionnaire.

Introduction: Despite evidence that expectancies influence the use and effects of drugs, there are no questionnaires that assess abstinence expectancies among smokers. Such a questionnaire may assist prediction models of successful quitting, enable clinicians to target specific expectancies, and give researchers a broader understanding of cognitive processes that influence smoking.

Methods: We aimed to develop a questionnaire that assesses, among daily smokers, expected short-term psychological and physiological consequences to (hypothetically) abstaining from smoking.