Simplified assay for VWF cleaving protease (ADAMTS13) activity and inhibitor in plasma.

The absence of VWF cleaving protease activity (VWFcp, ADAMTS13) has recently been identified as a central component in the pathogenesis of TTP. Several assays for the measurement of ADAMTS13 activity have been described, but most are cumbersome and employ techniques not easily adapted to routine laboratories. Thus, ADAMTS13 assays are available at only a few reference or research laboratories.

Immune reconstitution after hematopoietic stem-cell transplantation and its influence on respiratory infections.

Hematopoietic stem-cell transplantation has evolved as the best therapeutic option for many patients with hematologic malignancy, and it is becoming more common as a treatment for metabolic and autoimmune disorders. The conditioning regimen given before transplantation virtually eliminates all pre-existing immunity, and the resulting immune deficits leave the host susceptible to a variety of respiratory infections, many of which carry significant morbidity and mortality. These deficits resolve over time with re-constitution of the immune system.