Quantitative Predictors of Response to Neoadjuvant Chemotherapy on Dynamic Contrast-enhanced 3T Breast MRI.

Objective: To assess whether changes in quantitative parameters on breast MRI better predict pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer than change in volume.

Methods: This IRB-approved retrospective study included women with newly diagnosed breast cancer who underwent 3T MRI before and during NAC from January 2013 to December 2019 and underwent surgery at our institution. Clinical data such as age, histologic diagnosis and grade, biomarker status, clinical stage, maximum index cancer dimension and volume, and surgical pathology (presence or absence of in-breast pCR) were collected.

and Beyond: Comprehensive Image-rich Review of Hereditary Breast and Gynecologic Cancer Syndromes.

In addition to the well-characterized and hereditary breast and ovarian cancer syndromes, many other syndromes that are associated with genetic mutations predispose individuals to an increased risk of breast and gynecologic malignancies. Many mutated genes encode for tumor-suppressor products and are inherited in an autosomal dominant manner. Mutations markedly increase an individual's lifetime risk of cancers in different organ systems, depending on the associated syndrome.

Musculoskeletal interventional ultrasound.

Ultrasound is a nonionizing, low-cost, portable imaging technique for the evaluation of tendons, muscles, joints, soft tissue masses, and cysts, especially in patients unable to tolerate computed tomography or magnetic resonance imaging. These advantages make ultrasound an ideal modality for guiding musculoskeletal interventions. Its real-time capabilities allow continuous observation of needle placement into the targeted area and direct visualization of interventions such as injection of medication while avoiding other soft tissue structures or nearby neurovascular bundles.