Publications by authors named "Melissa L Edwards"

Objective: To report summative data from the American College of Veterinary Emergency and Critical Care (ACVECC)-Veterinary Committee on Trauma (VetCOT) registry, with further individual evaluation of university and private practices and level I and II Veterinary Trauma Centers (VTCs).

Design: Multi-institutional registry data report, January 1, 2020, to December 31, 2021.

Setting: VTCs identified and verified by ACVECC-VetCOT.

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Article Synopsis
  • The study investigates if baseline resting state fMRI can predict cognitive impairment after cancer treatment in breast cancer patients, which could improve patient care and reduce costs.
  • A total of 76 patients (some receiving chemotherapy and some not) and 50 healthy controls were assessed over time for executive dysfunction, memory function, and psychological distress.
  • Results showed increased executive dysfunction and decreased memory over time in chemotherapy patients compared to controls, and advanced modeling techniques effectively predicted these cognitive outcomes based on initial brain imaging data.
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Background: The presence of Subjective Cognitive Decline (SCD) in the absence of objective change and the inflammatory biomarker Alpha 2 Macroglobulin (A2M) have both been implicated in preclinical Alzheimer's disease. Mexican Americans are population with high rates of cardiovascular and inflammatory disorders.

Objectives: The current study investigated the levels of A2M in cognitively normal Mexican Americans with and without complaints of cognitive decline.

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The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) is an assessment of neuropsychological functioning commonly used in clinical and research settings. To our knowledge, normative data for the RBANS is not available for Hispanic, Mexican Americans, which the current study sought to establish. Data from 136 Hispanic, Mexican Americans from Project FRONTIER were analyzed.

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Objectives: To analyze the association between chronic kidney disease (CKD) and mild cognitive impairment (MCI) in Mexican Americans and to determine whether there is a blood-based proteomic profile linking CKD to MCI.

Design: Retrospective analysis of cohort study.

Setting: Health and Aging Brain among Latino Elders study.

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The Boston Naming Test is a neuropsychological measure of confrontation naming, short forms of which can be advantageous with various populations. The purpose of this study was to establish a Spanish-English equivalent version of the BNT using item response theory. Data were analyzed from 380 Project FRONTIER participants; 27 items differed between groups and were removed from the measure.

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Objective: Review the mechanisms of action and clinical application of hyperbaric oxygen therapy (HBOT) based on human and veterinary clinical and experimental literature.

Data Sources: Pubmed and Veterinary Information Network databases were searched for human and veterinary journal articles on hyperbaric therapy in clinically applicable situations. Historical reference searches on several articles in addition to basic physiologic concepts were also reviewed.

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Objective: Review the historical development and physiologic principles of hyperbaric oxygen therapy (HBOT) based on human and veterinary experimental literature and current equipment in use.

Data Sources: Review of basic physiologic concepts. Data from human and veterinary journals were reviewed through Pubmed and Veterinary Information Network database searches as well as reference searches on several articles covering hyperbaric therapy in clinically applicable situations.

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In human beings, rFVIIa has been used successfully to promote hemostasis in patients with various bleeding disorders. Patients with hemophilia, thrombocytopenia, and thrombocytopathy have been effectively and safely treated as well as patients with severe trauma or surgery resulting in profuse bleeding and patients with impaired liver function. Given these successes, the possibility of using rFVIIa in veterinary medicine is appealing.

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