Publications by authors named "Melissa Jane Green"
Mol Psychiatry
October 2024
Article Synopsis
- Formal thought disorder (FTD) is a key symptom of schizophrenia, but its exact neurobiological causes and correlation with brain volume loss are still unclear, which this study seeks to address using a large cohort of patients and controls.
- The research focuses on differentiating between positive, negative, and total formal thought disorder while investigating brain structural changes and their cellular bases using virtual histology tools.
- Findings reveal distinct neural networks for positive and negative FTD, with negative FTD showing preserved orbitofrontal thickness and both FTD types linked to unique cellular fingerprint patterns, advancing our understanding of the disorder.
