Publications by authors named "Melissa J Michmerhuizen"
Mass balance, metabolism, and excretion of ABT-126, an 7 neuronal acetylcholine receptor agonist, were characterized in healthy male subjects ( = 4) after a single 100-mg (100 Ci) oral dose. The total recovery of the administered radioactivity was 94.0% (±2.
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- - Venetoclax (ABT-199) is a B-cell lymphoma-2 (Bcl-2) inhibitor being developed for blood cancers, with studies showing that after a single oral dose in humans, the complete radioactive dose was recovered, mainly through feces, while very little was excreted in urine.
- - Around 65% of venetoclax is absorbed, with about 66% of the dose processed by the liver, resulting in several metabolites, including the unchanged drug and its nitro reduction metabolite M30, which was mostly found in feces.
- - One significant metabolite, M27, accounts for 12% of the drug-related material and is formed mainly through the cyto
This manuscript details the construction of a fully automated flow hydrogenation apparatus for use in high-throughput organic synthesis. The instrument comprises of a Bohdan robot platform coupled with a ThalesNano H-cube hydrogenator and a series of solvent valves and pumping mechanisms. Using this instrument, we have been able to fully automate a number of key transformations that could not otherwise be conveniently undertaken in a high-throughput manner.
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