Antiproliferative Activity and Mechanisms of Action of Plant-derived Flavonoids on Breast Cancer.

Breast cancer is one of the main global diseases with a high mortality rate that mainly affects the female population. Despite the important advances that have been made concerning the treatments for this disease, research on less invasive therapies that generate fewer side effects for patients continues to develop. Consequently, researchers have turned their attention to using natural compounds (such as flavonoids) involved in molecular processes implicated in this type of cancer and are studying how these processes can be exploited to develop possible chemotherapies.

Loading and Release of Phenolic Compounds Present in Mexican Oregano () in Different Chitosan Bio-Polymeric Cationic Matrixes.

Mexican oregano () polyphenols have antioxidant and anti-inflammatory potential, but low bioaccessibility. Therefore, in the present work the micro/nano-encapsulation of these compounds in two different matrixes of chitosan (CS) and chitosan--poly(PEGMA) (CS--PPEGMA) is described and assessed. The particle sizes of matrixes of CS (~955 nm) and CS--PPEGMA (~190 nm) increased by 10% and 50%, respectively, when the phenolic compounds were encapsulated, yielding loading efficiencies (LE) between 90-99% and 50-60%, correspondingly.