Publications by authors named "Melissa G Stevens"
Article Synopsis
- EAAT5 is a unique glutamate transporter found in the retina, primarily in bipolar neurons and photoreceptors, functioning as both a slow transporter and a glutamate-gated inhibitory receptor.
- Researchers have discovered five new splice variants of EAAT5 through PCR cloning and sequencing, which skip parts of the original genetic code.
- Each of these variants is confirmed to be present at the protein level, suggesting that they may have different properties compared to the full-length EAAT5 based on their structural differences.
The choroid plexus is a structure within each ventricle of the brain that is composed of fenestrated vessels surrounded by secretory epithelial cells. The epithelial cells are linked by tight junctions to create a permeability barrier. The epithelial cells are derived from neuroectoderm, and are thus defined by some authors as a subtype of macroglia.
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- GLT-1 (EAAT2) is a key glial glutamate transporter in the mammalian brain, crucial for terminating neurotransmitter signals at excitatory synapses.
- A new splice variant of GLT-1, where exon 4 is skipped, was isolated from adult rat brain tissue through RT-PCR and encodes a 500 amino acid protein.
- The study found that this variant's mRNA is present in various brain regions and certain tissues, and suggests it could either function as a glutamate transporter or modulate the function of other glutamate transporters.