Publications by authors named "Melissa Foglietta"
Article Synopsis
- Acute coronary syndrome, cardiac surgery, and structural interventions frequently lead to the use of allogeneic red blood cells due to bleeding and anemia.
- The variability in blood transfusion use arises from limited data and a lack of clear guidelines, with an emphasis on avoiding unnecessary transfusions unless absolutely necessary.
- Future research needs to determine the role of blood transfusions in adverse events during cardiac interventions, and this review summarizes current literature and critiques the evidence surrounding their use.
Although the entire vascular bed is constantly exposed to the same risk factors, atherosclerosis manifests a distinct intra-individual pattern in localization and progression within the arterial vascular bed. Despite shared risk factors, the development of atherosclerotic plaques is influenced by physical principles, anatomic variations, metabolic functions, and genetic pathways. Biomechanical factors, particularly wall shear stress (WSS), play a crucial role in atherosclerosis and both low and high WSS are associated with plaque progression and heightened vulnerability.
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- - De-escalation of dual antiplatelet therapy (DAPT) is being explored to minimize bleeding risks while still protecting against heart-related issues, but doing so indiscriminately in high-risk patients may lead to serious heart events.
- - Emerging tools, like platelet function and genetic tests, could help tailor DAPT de-escalation, but they come with their own challenges and limitations.
- - High-risk patients, often excluded from clinical trials, lack specific guidelines, making the decision on how to adjust DAPT complex and needing personalized approaches.
: Dabigatran etexilate is a pro-drug hydrolyzed into dabigatran by carboxylesterases (CES) and is a substrate of the P-Glycoprotein encoded by the adenosine-triphosphate-binding cassette sub-family B member (ABCB)1 genes. We evaluated the functional response to dabigatran according to different CES1 and ABCB1 single-nucleotide polymorphisms (SNPs) in patients with atrial fibrillation (AF). : A total of 100 consecutive patients with AF taking dabigatran were enrolled by two Italian centers.
View Article and Find Full Text PDFCurrent evidence supports device-based transcatheter interventions for the management of patients with structural heart disease, proving well their safety and efficacy; transcatheter aortic valve implantation (TAVI), transcatheter edge-to-edge repair (TEER) of mitral or tricuspid valves, and left atrial appendage occlusion (LAAO) are expanding their role in contemporary practice. Currently, guidelines recommend performing TAVI in 'Heart Valve Center' with interventional cardiology and institutional on-site cardiac surgery (iOSCS), while no site limitation has been defined for TEER and LAAO. The growing number of candidates for transcatheter interventions generates long waiting times with negative consequences on mortality, morbidity, hospitalization, and functional deterioration.
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- Patent foramen ovale (PFO) is a common heart condition found in many people that can cause strokes in young people.
- New studies show that a procedure to close PFO is better than just taking medicine to prevent future strokes.
- It's important to check specific heart features to understand if someone with PFO is at a higher risk for having more strokes.
A pro-thrombotic milieu and a higher risk of thrombotic events were observed in patients with CoronaVirus disease-19 (COVID-19). Accordingly, recent data suggested a beneficial role of low molecular weight heparin (LMWH), but the optimal dosage of this treatment is unknown. We evaluated the association between prophylactic vs.
View Article and Find Full Text PDFBackground: Risk of atrial fibrillation (AF) in masked and white coat uncontrolled hypertension (MUCH and WUCH, respectively) has not yet been investigated. We assessed the risk of new-onset AF in MUCH and WUCH detected by ambulatory blood pressure (BP) monitoring.
Methods: The occurrence of AF was evaluated in 2,135 treated hypertensive patients aged >40 years, with baseline sinus rhythm, by electrocardiogram.