Rock Climbing-Related Injuries: A Clinical and Imaging Overview.

The rise in popularity of competitive and recreational rock climbing, particularly following its inclusion in the 2021 Summer Olympics, has led to a corresponding increase in rock climbing-related injuries. Due to the sport's unique biomechanical demands, it often presents injuries not commonly seen in other sports. Additionally, although some injuries align with those encountered in other sports, they manifest through distinctive climbing-related mechanisms unfamiliar to many clinicians.

Real-Time Ambulatory ECG Does Not Expedite Care.

Background: Ambulatory ECG (AECG) monitoring is pivotal to the diagnosis of arrhythmias and can be performed with near "real-time" notification of abnormalities. There are limited data on the relative benefit of real-time monitoring compared with traditional Holter monitoring.

Methods And Results: This is a retrospective observational analysis of University of Utah Health patients who underwent ambulatory ECG studies from 2010 to 2022.

Protocol Development and Initial Experience With Intravenous Sotalol Loading for Atrial Arrhythmias.

Background: Oral sotalol is a class III antiarrhythmic commonly used for the maintenance of sinus rhythm in patients with atrial fibrillation (AF). Recently, the Food and Drug Administration (FDA) approved the use of IV sotalol loading, based primarily on modeling data for the infusion. We aimed to describe a protocol and experience with IV sotalol loading for elective treatment of adult patients with AF and atrial flutter (AFL).

Autophagy-lysosome pathway alterations and alpha-synuclein up-regulation in the subtype of neuronal ceroid lipofuscinosis, CLN5 disease.

Neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative lysosomal storage disorders. CLN5 deficiency causes a subtype of NCL, referred to as CLN5 disease. CLN5 is a soluble lysosomal protein with an unclear function in the cell.

Glutamine-dependent lysosome homeostatic changes induced by starvation and lysosome inhibition.

Lysosomes are a major organelle for degrading macromolecules. When deprived of nutrients, cells activate the autophagy and lysosome biogenesis pathways to recycle cytoplasmic materials and to increase lysosomal degradation capacity for survival, respectively. We have identified a condition in which cells accumulated enlarged lysosomes upon starvation and lysosome inhibition.