The pancreas-specific form of secretory pathway calcium ATPase 2 regulates multiple pathways involved in calcium homeostasis.

Acinar cell exocytosis requires spatiotemporal Ca signals regulated through endoplasmic reticulum (ER) stores, CaATPases, and store-operated Ca entry (SOCE). The secretory pathway CaATPase 2 (SPCA2) interacts with Orai1, which is involved in SOCE and store independent Ca entry (SICE). However, in the pancreas, only a C-terminally truncated form of SPCA2 (termed SPAC2C) exists.

Atp2c2 Is Transcribed From a Unique Transcriptional Start Site in Mouse Pancreatic Acinar Cells.

Proper regulation of cytosolic Ca(2+) is critical for pancreatic acinar cell function. Disruptions in normal Ca(2+) concentrations affect numerous cellular functions and are associated with pancreatitis. Membrane pumps and channels regulate cytosolic Ca(2+) homeostasis by promoting rapid Ca(2+) movement.