White adults' color-evasive racial attitudes and racism emotionality: Understanding patterns and correlates.

There is limited empirical work that examines how Whites psychologically maintain and make efforts to dismantle systemic racism. Prior work suggests that both color-evasive attitudes and aspects of racism emotionality predict Whites' behaviors and, to a lesser extent, their well-being as their racial position is challenged. Utilizing a sample of 897 White adults attending college ( = 22.

Mass Spectrometry Defines Lysophospholipids as Ligands for Chicken MHCY Class I Molecules.

Chicken (Gallus gallus) MHCY class I molecules are highly polymorphic yet substantially different from polymorphic MHC class I molecules that bind peptide Ags. The binding grooves in MHCY class I molecules are hydrophobic and too narrow to accommodate peptides. An earlier structural study suggested that ligands for MHCY class I might be lipids, but the contents of the groove were not clearly identified.

The associations of maternal/paternal modeling, self-efficacy, and ethnic fit on math/science achievement among Latinx students.

Introduction: This paper examined individual, family, and peer roles in promoting Latinx youths' math and science performance. The role of maternal/paternal modeling in education was examined as shaping academic self-efficacy and, in turn, math/science grades among a population considered at risk of low academic achievement. Moreover, the study tested the moderating roles of class ethnic fit (i.

Latinx adolescents' academic self-efficacy: Explaining longitudinal links between ethnic-racial identity and educational adjustment.

Objective: This longitudinal study had three aims: (a) to examine whether ethnic-racial identity (ERI; i.e., public regard, private regard, and centrality) was associated with academic self-efficacy and changes in educational adjustment (i.

Mechanical regulation of cell size, fate, and behavior during asymmetric cell division.

Asymmetric cell division (ACD) is an evolutionary conserved mechanism used by prokaryotes and eukaryotes alike to generate cell diversity. ACD can be manifested in biased segregation of macromolecules or differential partitioning of cell organelles. Cells are also constantly subject to extrinsic or intrinsic mechanical forces, influencing cell behavior and fate.

The Distal Role of Adolescents' Awareness of and Perceived Discrimination on Young Adults' Socioeconomic Attainment among Mexican-Origin Immigrant Families.

Cultural-ecological frameworks posit that there are harmful effects of social stratification on developmental outcomes. In particular, awareness of aspects of social stratification in society and interpersonal experiences of discrimination, more generally and within specific contexts, may differentially influence outcomes across life stages; yet, few studies have examined the distal effects during adolescence on early adult developmental outcomes. The current study fills this gap by examining distal mechanisms linking adolescents' (Time 1: ages 13-15) awareness of and perceived general and school discrimination to young adults' (Time 3: ages 23-25) socioeconomic attainment (i.

Mexican-Origin Parents' Stress and Satisfaction: The Role of Emotional Support.

Guided by a process model of parenting and the integrative model, this study examined sources of emotional support (i.e., partner, maternal, paternal) as related to stress and satisfaction resulting from the parenting role in a sample of Mexican-origin young adult parents who participated in the National Longitudinal Study of Adolescent to Adult Health (Add Health) during Wave IV.

Mexican-origin Adolescents' Educational Expectation Trajectories: Intersection of Nativity, Sex, and Socioeconomic Status.

Expectancy value theory and a cultural-ecological framework are integrated in this study to examine the trajectories of 246 Mexican-origin adolescents' (M = 12.52, SD = 0.58; 51% girls, 62% U.

Discrimination, Parent-Adolescent Conflict, and Peer Intimacy: Examining Risk and Resilience in Mexican-Origin Youths' Adjustment Trajectories.

Peer discrimination and parent-adolescent conflict in early adolescence were examined as predictors of depressive symptoms and risky behaviors from early to late adolescence using four waves of data over an 8-year period from a sample of 246 Mexican-origin adolescents (M  = 12.55, SD = 0.58; 51% female).

Synthesis, Positron Emission Tomography Imaging, and Therapy of Diabody Targeted Drug Lipid Nanoparticles in a Prostate Cancer Murine Model.

The blood clearance of chemotherapeutic drugs such as doxorubicin (Dox) can be extended by incorporation into lipid nanoparticles (LNPs) and further improved by tumor targeting with antibody fragments. We used positron emission tomography (PET) imaging in a murine prostate cancer model to evaluate tumor targeting of LNPs incorporating Dox and antiprostate-specific membrane antigen (PSMA) diabodies. Dox-LNPs were generated by mixing or covalent attachment to water soluble distearoylphosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG).

Prospective Relations among Low-Income African American Adolescents' Maternal Attachment Security, Self-Worth, and Risk Behaviors.

This study examined prospective mediating relations among mother-adolescent attachment security, self-worth, and risk behaviors, including substance use and violence, across ages 13-17 in a sample of 901 low-income African American adolescents. Path analyses revealed that self-worth was a significant mediator between attachment security and risk behaviors, such that earlier attachment security predicted self-worth 1 year later, which in turn, predicted substance use, weapon carrying, and fighting in the 3rd year. Implications for the role of the secure base concept within the context of urban poverty are discussed.

PET imaging of Cu-DOTA-scFv-anti-PSMA lipid nanoparticles (LNPs): Enhanced tumor targeting over anti-PSMA scFv or untargeted LNPs.

Introduction: Single chain (scFv) antibodies are ideal targeting ligands due to their modular structure, high antigen specificity and affinity. These monovalent ligands display rapid tumor targeting but have limitations due to their fast urinary clearance.

Methods: An anti-prostate membrane antigen (PSMA) scFv with a site-specific cysteine was expressed and evaluated in a prostate cancer xenograft model by Cu-64 PET imaging.

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10(-20)), ER-negative BC (P=1.

Blood pressure profile in pregnancy: The impact of its duration on results and patients' well-being.

Background: A blood pressure profile (BPP) is often used to diagnose and manage hypertension in pregnancy. However, there is no consensus on the number and interval of blood pressure (BP) readings required.

Aims: To ascertain whether BP readings at 15-min interval over one hour yields clinically equivalent results to readings at 60-min interval over three hours.

Exposure to methylphenidate during peri-adolescence affects endocrine functioning and sexual behavior in female Long-Evans rats.

The present study was designed to test the effects of methylphenidate (MPH) exposure on the maturation of endocrine functioning and sexual behavior. Female rat pups received either MPH (2.0mg/kg, i.

How Do My Friends Matter? Examining Latino Adolescents' Friendships, School Belonging, and Academic Achievement.

Are Latino adolescents' friendships an untapped resource for academic achievement or perhaps one of the reasons why these youth struggle academically? Using data from the National Longitudinal Study of Adolescent Health (N = 6782; 7th through 12th graders; 52.9 % female), we examined whether the process of Latino students' school belonging mediated the relationships between the context of friendships (i.e.

Molecular Analysis of Mixed Endometrioid and Serous Adenocarcinoma of the Endometrium.

Background: The molecular biology and cellular origins of mixed type endometrial carcinomas (MT-ECs) are poorly understood, and a Type II component of 10 percent or less may confer poorer prognoses.

Methodology/principal Findings: We studied 10 cases of MT-EC (containing endometrioid and serous differentiation), 5 pure low-grade endometrioid adenocarcinoma (EAC) and 5 pure uterine serous carcinoma (USC). Endometrioid and serous components of the MT-ECs were macrodissected and the expression of 60 candidate genes compared between MT-EC, pure USC and pure EAC.

Economic hardship and Mexican-origin adolescents' adjustment: examining adolescents' perceptions of hardship and parent-adolescent relationship quality.

Studies examining economic hardship consistently have linked family economic hardship to adolescent adjustment via parent and family functioning, but limited attention has been given to adolescents' perceptions of these processes. To address this, the authors investigated the intervening effects of adolescents' perceptions of economic hardship and of parent-adolescent warmth and conflict on the associations between parental economic hardship and adolescent adjustment (i.e.

C60-ToF SIMS imaging of frozen hydrated HeLa cells.

Sample preparation continues to be a major challenge for secondary ion mass spectrometry studies of biological materials. Maintaining the native hydrated state of the material is important for preserving both chemical and spatial information. Here, we discuss a method which combines a sample wash and dry protocol discussed by Berman followed by plunge freezing in liquid ethane for a frozen-hydrated analysis of mammalian cells (HeLa).

Socioeconomic status, ethnicity, culture, and immigration: examining the potential mechanisms underlying Mexican-origin adolescents' organized activity participation.

The integrative model for child development and ecodevelopmental theory suggest that macro factors, such as socioeconomic status, ethnicity, culture, and immigration influence the settings in which adolescents engage. The goal of this investigation was to use a combination of deductive and inductive qualitative analysis to describe the mechanisms by which these macro factors might be related to Mexican-origin adolescents' participation in organized after-school activities. Qualitative data were collected through focus group interviews with 44 adolescents, 50 parents, and 18 activity leaders from 2 neighborhoods that varied in ethnic composition and average family income.

Discrimination and Mexican-origin adolescents' adjustment: the moderating roles of adolescents', mothers', and fathers' cultural orientations and values.

Drawing on García Coll et al.'s integrative framework and the risk and resilience model, this study examined the relationships between adolescents' perceived discrimination and psychosocial adjustment and the moderating roles of adolescents', mothers', and fathers' cultural orientations and values, and adolescent gender in a sample of 246 Mexican-origin families. Using multilevel modeling with data from mothers, fathers, seventh graders (M (age) = 12.

Exploring Mothers' and Fathers' Relationships with Sons Versus Daughters: Links to Adolescent Adjustment in Mexican Immigrant Families.

Drawing on ecological and gender socialization perspectives, this study examined mothers' and fathers' relationships with young adolescents, exploring differences between mothers and fathers, for sons versus daughters, and as a function of parents' division of paid labor. Mexican immigrant families (N = 162) participated in home interviews and seven nightly phone calls. Findings revealed that mothers reported higher levels of acceptance toward adolescents and greater knowledge of adolescents' daily activities than did fathers, and mothers spent more time with daughters than with sons.

Conflict Resolution in Mexican American Adolescents' Friendships: Links with Culture, Gender and Friendship Quality.

This study was designed to describe the conflict resolution practices used in Mexican American adolescents' friendships, to explore the role of cultural orientations and values and gender-typed personality qualities in conflict resolution use, and to assess the connections between conflict resolution and friendship quality. Participants were 246 Mexican American adolescents (M = 12.77 years of age) and their older siblings (M = 15.

Mexican American Fathers' Occupational Conditions: Links to Family Members' Psychological Adjustment.

To examine the implications of fathers' occupational conditions (i.e., income, work hours, shift work, pressure, workplace racism, and underemployment) for family members' psychological adjustment, home interviews were conducted with fathers, mothers, and two adolescent offspring in each of 218 Mexican American families.

The relationship between interstitial cystitis and endometriosis in patients with chronic pelvic pain.

Objective: This study was designed to determine the relationship between interstitial cystitis (IC), endometriosis (endo), and chronic pelvic pain (CPP) in individuals in whom nongynecological and nonurological problems had been previously ruled out.

Methods: A prospective study of 162 consecutive women with a complaint of chronic pelvic pain seen in the clinic was performed between August 2002 and December 2005. These patients underwent a workup to exclude other causes of pelvic pain, had PUF (Pain Urgency and Frequency) questionnaires filled out, and underwent a laparoscopy and a cystoscopy with hydrodistention.