Publications by authors named "Melissa Benavente"
Background: Idiopathic nephrotic syndrome (INS) is a heterogenous disease and current classification is based on observational responses to therapies or kidney histology. The National Unified Renal Translational Research Enterprise (NURTuRE)-INS cohort aims to facilitate novel ways of stratifying INS patients to improve disease understanding, therapeutics and design of clinical trials.
Methods: NURTuRE-INS is a prospective cohort study of children and adults with INS in a linked biorepository.
Article Synopsis
- The study examines factors affecting health-related quality of life (HRQoL) in patients with chronic kidney disease (CKD), focusing on potentially modifiable aspects that could be targeted for improvement.
- Researchers analyzed data from nearly 3000 CKD patients, collecting diverse information and using specific measures to assess HRQoL, finding that a significant percentage reported issues in various life dimensions.
- Results indicated that poorer HRQoL was strongly associated with obesity, depression, anxiety, medication burden, sarcopenia, low hemoglobin levels, and pain, highlighting areas for potential intervention.
Background: Chronic kidney disease (CKD) is common but heterogenous and is associated with multiple adverse outcomes. The National Unified Renal Translational Research Enterprise (NURTuRE)-CKD cohort was established to investigate risk factors for clinically important outcomes in persons with CKD referred to secondary care.
Methods: Eligible participants with CKD stages G3-4 or stages G1-2 plus albuminuria >30 mg/mmol were enrolled from 16 nephrology centres in England, Scotland and Wales from 2017 to 2019.