Publications by Melissa Beilschmidt

Publications by authors named "Melissa Beilschmidt"

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Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment.

Robin M Hallett Ester Bonfill-Teixidor Raffaella Iurlaro Alexandra Arias Swetha Raman Melissa Beilschmidt

Clin Cancer Res

February 2023

Article Synopsis

LIF, a multifunctional cytokine, is linked to tumor development and progression, making it a potential therapeutic target in cancer treatment.
The study developed a high-affinity antibody called MSC-1 that effectively inhibits LIF signaling and tested its effects in immune-competent cancer models.
Results showed that MSC-1 increased antitumor activity and enhanced immune response when combined with anti-PD1, indicating its promise as a cancer immunotherapy agent.

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Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.

Swetha Raman Melissa Beilschmidt Minh To Kevin Lin Francine Lui

Proc Natl Acad Sci U S A

April 2019

Aberrant activation of Wnt/β-catenin signaling occurs frequently in cancer. However, therapeutic targeting of this pathway is complicated by the role of Wnt in stem cell maintenance and tissue homeostasis. Here, we evaluated antibodies blocking 6 of the 10 human Wnt/Frizzled (FZD) receptors as potential therapeutics.