Primary extragonadal yolk sac tumor originating from adrenal gland.

Extragonadal germ cell tumors are germ cell tumors with no evidence of a primary tumor within the gonads, most often located in the mediastinum or retroperitoneum. We present an extragonadal yolk sac tumor that presented as an adrenal carcinoma and required left adrenalectomy, nephrectomy, and significant IVC thrombectomy. This case, to our knowledge, is the first documented case of extragonadal yolk sac tumor originating from the adrenal gland.

Pseudomonas Quinolone Signal Induces Oxidative Stress and Inhibits Heme Oxygenase-1 Expression in Lung Epithelial Cells.

causes lung infections in patients with cystic fibrosis (CF). The quinolone signal (PQS) compound is a secreted virulence factor that contributes to the pathogenicity of We were able to detect PQS in sputum samples from CF patients infected with but not in samples from uninfected patients. We then tested the hypothesis that PQS induces oxidative stress in host cells by determining the ability of PQS to induce the production of reactive oxygen species (ROS) in lung epithelial cells (A549 and primary normal human bronchial epithelial [NHBE]) cells and macrophages (J774A.