Publications by authors named "Melissa Ait Said"
Postintegration transcriptional silencing of HIV-1 leads to the establishment of a pool of latently infected cells. In these cells, mechanisms controlling RNA Polymerase II (RNAPII) pausing and premature transcription termination (PTT) remain to be explored. Here, we found that the cleavage and polyadenylation (CPA) factor PCF11 represses HIV-1 expression independently of the other subunits of the CPA complex or the polyadenylation signal located at the 5' LTR.
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- - Recent research highlights the role of mA methylation in regulating HIV-1 replication, showing that specific enzymes (writers and erasers) control this modification on HIV-1 RNAs, which is crucial for viral gene expression regulation.
- - The study identifies the YTHDC1 protein as a key nuclear writer that influences the levels of HIV-1 RNAs and is necessary for the production of infectious HIV-1 particles, demonstrating its impact on the virus's RNA biogenesis and protein production.
- - Findings reveal that knocking down YTHDC1 increases certain HIV-1 RNA levels and negatively affects viral protein expression, suggesting that it plays a critical role in maintaining viral infectivity through its regulation of HIV-1 transcript processing.