Publications by authors named "Melissa A O'Banion"
Bioorg Med Chem Lett
November 2013
Article Synopsis
- The study explores the addition of a critical exocyclic enone to the natural alkaloid (-)-eburnamonine, enhancing its chemical properties and biological function.
- The modification significantly increases its anticancer activity and reactivity with nucleophilic thiols, assessed using quantitative NMR without deuterated solvents.
- The synthetic method achieved a 40% overall conversion rate, employing a modified Peterson olefination technique to effectively introduce the enone despite substantial steric hindrance.
