Stabilization of the human cytomegalovirus UL136p33 reactivation determinant overcomes the requirement for UL135 for replication in hematopoietic cells.

Human cytomegalovirus (HCMV) is a beta herpesvirus that persists indefinitely in the human host through a latent infection. The polycistronic gene locus of HCMV encodes genes regulating latency and reactivation. While is pro-latency, restricting virus replication in CD34 hematopoietic progenitor cells (HPCs), overcomes this restriction and is required for reactivation.

UL135 and UL136 Epistasis Controls Reactivation of Human Cytomegalovirus.

Unlabelled: Human cytomegalovirus (HCMV) is beta herpesvirus that persists indefinitely in the human host through a protracted, latent infection. The polycistronic gene locus of HCMV encodes genes regulating latency and reactivation. While UL138 is pro-latency, restricting virus replication in CD34+ hematopoietic progenitor cells (HPCs), UL135 overcomes this restriction for reactivation.