Publications by authors named "Melisa Semenas"
Skelet Muscle
October 2020
Article Synopsis
- Duchenne muscular dystrophy (DMD) is a muscle-wasting condition caused by dystrophin loss, with current treatments insufficient for muscle damage during eccentric contractions.
- A study using MDX mice indicated that exercise-induced muscle injury significantly reduces nicotinamide adenine dinucleotide (NAD) levels, vital for muscle health; strategies tested to enhance NAD levels included a precursor and a CD38 inhibitor.
- While inhibiting CD38 showed more potential than supplementing with the precursor, neither method resulted in sustained increases in NAD levels, muscle damage reduction, or improved strength after muscle stress.
