Publications by authors named "Melisa L Frisby"
Article Synopsis
- The study used diffusion tensor imaging (DTI) to examine brain structures in 36 mild traumatic brain injury (mTBI) patients compared to 37 orthopedic injury participants, aiming to identify recovery patterns.
- While no significant differences in brain structure among groups were found at baseline or follow-up, the orthopedic group showed increased global mean diffusivity in gray and white matter over time.
- DTI revealed elevated radial diffusivity in the corona radiata for mTBI at baseline, suggesting potential injury-related edema, though changes were not significant when looking at mTBI patients over time.
The neurological outcome scale for traumatic brain injury (NOS-TBI) is a measure assessing neurological functioning in patients with TBI. We hypothesized that the NOS-TBI would exhibit adequate concurrent and predictive validity and demonstrate more sensitivity to change, compared with other well-established outcome measures. We analyzed data from the National Acute Brain Injury Study: Hypothermia-II clinical trial.
View Article and Find Full Text PDFObject: The authors hypothesized that cooling before evacuation of traumatic intracranial hematomas protects the brain from reperfusion injury and, if so, further hypothesized that hypothermia induction before or soon after craniotomy should be associated with improved outcomes.
Methods: The National Acute Brain Injury Study: Hypothermia I (NABIS:H I) was a randomized multicenter clinical trial of 392 patients with severe brain injury treated using normothermia or hypothermia for 48 hours with patients reaching 33°C at 8.4 ± 3 hours after injury.