Publications by authors named "Melinder K Gill"
Article Synopsis
- Amyotrophic lateral sclerosis (ALS) is a deadly neurodegenerative disease that presents various clinical challenges and complex genetics, complicating understanding and treatment efforts.* -
- To address this, researchers created human induced pluripotent stem cells (iPSCs) from different ALS patients - including sporadic and familial cases - as well as healthy controls.* -
- These iPSCs can be used to develop 2D and 3D models of ALS, aiding in the study of disease mechanisms and the identification of potential therapies.*
In humans, there are two arylamine N-acetyltransferase genes that encode functional enzymes ( and ) as well as one pseudogene, all of which are located together on chromosome 8. Although they were first identified by their role in the acetylation of drugs and other xenobiotics, recent studies have shown strong associations for both enzymes in a variety of diseases, including cancer, cardiovascular disease, and diabetes. There is growing evidence that this association may be causal.
View Article and Find Full Text PDFAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease in which the TDP-43 protein is believed to play a central role in disease pathophysiology. Using the CRISPR-Cas9 system, we introduced the heterozygous c.1144G > A (p.
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