Publications by authors named "Melinda J Carter"
Article Synopsis
- This study investigated how therapeutic apheresis affects chemokine gradients and leukocyte movement in a rat model of sepsis.
- The researchers found that apheresis significantly reduced plasma chemokines, which increased the recruitment of leukocytes to the infected peritoneal cavity while decreasing their presence in healthy tissues like the lung.
- Overall, the findings suggest that apheresis can enhance the body's immune response to infections by actively controlling the distribution of immune cells and reducing tissue damage.
The effect of extracorporeal blood purification on clinical outcomes in sepsis is assumed to be related to modulation of plasma cytokine concentrations. To test this hypothesis directly, we treated rats that had a cecal ligation followed by puncture (a standard model of sepsis) with a modest dose of extracorporeal blood purification that did not result in acute changes in a panel of common cytokines associated with inflammation (TNF-α, IL-1β, IL-6, and IL-10). Pre- and immediate post-treatment levels of these cytokines were unchanged compared to the sham therapy of extracorporeal circulation without blood purifying sorbent.
View Article and Find Full Text PDFObjective: A broad-spectrum immune-regulating therapy could be beneficial in the treatment of sepsis. Our previous studies have shown that a hemoadsorption device (CytoSorb) removes both pro- and anti-inflammatory cytokines and improves survival in experimental endotoxemia. We sought to determine whether hemoadsorption can also be effective in the treatment of sepsis.
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