Publications by authors named "Melina Terlinden"
Pre-existing anti-drug antibodies in Fabry disease show less affinity for pegunigalsidase alfa.
Mol Ther Methods Clin Dev
September 2022
Article Synopsis
- * Pull-down experiments indicated that PEGylation of PRX-102 masks certain epitopes, which likely contributes to the reduced ADA affinity and a notable decrease in inhibitory effects on PRX-102.
- * Our findings suggest that switching from traditional treatments to PRX-102 could be beneficial for patients with pre-existing ADAs, and this transition is currently being tested in clinical trials