Publications by authors named "Melina Rojas"
Purpose: Infertility is a global health issue and nutrition plays a significant role in fertility outcomes. We aimed to investigate the cross-sectional and prospective associations of glycemic index (GI) and glycemic load (GL) with semen quality parameters in a cohort of healthy young men.
Materials And Methods: The study included 106 men aged 18-35 years from the FERTINUTS trial.
Background: Alzheimer's disease (AD) diagnosis relies on clinical symptoms complemented with biological biomarkers, the Amyloid Tau Neurodegeneration (ATN) framework. Small non-coding RNA (sncRNA) in the blood have emerged as potential predictors of AD. We identified sncRNA signatures specific to ATN and AD, and evaluated both their contribution to improving AD conversion prediction beyond ATN alone.
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- Telomere length (TL) serves as a marker for age-related diseases, with oxidative stress and inflammation accelerating its shortening, leading to cellular aging.
- The study examined the connection between various lipoprotein subfractions and TL and telomerase activity-related gene expression in 54 pre-diabetic individuals, using advanced statistical methods to find significant associations.
- Key findings revealed that smaller HDL particles correlated with shorter telomeres and reduced gene expression, while larger HDL particles were linked to longer telomeres, highlighting the importance of lipoprotein profiles in chronic disease risk assessment.
Article Synopsis
- New dietary strategies are being researched to prevent cognitive decline, but current evidence mainly comes from food and nutrient supplements, showing inconsistent results.
- A thorough review of randomized controlled trials from 2018 to 2021 identified 61 relevant studies, suggesting that certain dietary patterns, especially the Mediterranean diet, may beneficially affect cognitive function.
- While healthy eating is associated with improved cognitive performance, the overall quality of the studies is low, and results on the effectiveness of dietary supplements vary, highlighting the need for more robust trials to inform dietary recommendations.