Publications by authors named "Melina P Cazorla-Bak"

Article Synopsis
  • SGLT2 inhibitors like dapagliflozin are being studied for their protective effects on the kidneys in diabetic patients, particularly regarding how they influence oxygen levels within different regions of the kidney.
  • The study measured kidney oxygen tension and other related factors in diabetic rats to understand the effects of SGLT2 inhibition on various kidney regions.
  • Results showed that while superficial kidney regions maintained oxygen levels, deeper regions experienced significant oxygen reduction, leading to changes in kidney function and increased production of erythropoietin.
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Purpose: The kidney plays a central physiologic role as an oxygen sensor. Nevertheless, the direct mechanism by which this occurs is incompletely understood. We measured renal microvascular partial pressure of oxygen (PO) to determine the impact of clinically relevant conditions that acutely change PO including hyperoxia and hemodilution.

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This narrative review critically evaluates the evidence for risk of anemia and red blood cell (RBC) transfusion. For this purpose, it assesses large prospective randomized-controlled trials (RCTs) in medical, surgical, and critical care patient populations in which the impact of specific hemoglobin transfusion thresholds are compared. In these trials, the risks of anemia relative to those of RBC transfusion are assessed.

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