Publications by authors named "Melina De Bruycker"
Article Synopsis
- Peroxisomal 3-ketoacyl-CoA thiolase B (Thb) plays a crucial role in β-oxidation of fatty acids in peroxisomes and is activated by the nuclear hormone receptor PPARα through the compound Wy14,643 (Wy).
- Mice lacking Thb showed reduced peroxisomal β-oxidation when treated with Wy, while mitochondrial β-oxidation remained unaffected, indicating Thb's specific role in fatty acid metabolism.
- The absence of Thb led to a failure to upregulate cholesterol biosynthesis genes in response to Wy, suggesting Thb's involvement in cholesterol regulation and highlighting the potential of targeting peroxisomes for treating cholesterol imbalances in
Defects in the formation of the cerebral cortex and the cerebellum are a prominent feature of the peroxisome biogenesis disorder Zellweger syndrome and in mouse models for this disease. The aim of the present study was to investigate the impact of liver and brain peroxisomes on neurodevelopment by analyzing mice with tissue-selective elimination of peroxisomes. To this end, Pex5-loxP mice were bred with albumin/alpha-fetoprotein (Alfp)-Cre and nestin (Nes)-Cre mice.
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