Synthesis, characterization, COX1/2 inhibition and molecular modeling studies on novel 2-thio-diarylimidazoles.

Heterocyclic compounds with diaryl substituents have been a milestone approach for selective cyclooxygenase 2 (COX 2) inhibition by bioisosteric replacements and modifications. It is also known that thiazole derivatives have different pharmacological activities. In this study, nine novel 2-[(1,5-diphenyl-1-imidazole-2-yl)thio]-N-(thiazole-2-yl)acetamide derivatives (Compound ) were synthesized via the reaction of 1,5-disubstitued phenyl-imidazole-2-thiole and -thiazole acetamide.