Publications by Melike Dogan Unlu

Publications by authors named "Melike Dogan Unlu"

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A novel insight into the neuroprotective effects of cannabidiol: maintained apelin/dopamine synthesis, NRF2 signaling, and AKT/CREB/BDNF gene expressions.

Melike Doğan Ünlü Sanem Aşçı Orhan İmeci Adem Milletsever Özlem Özmen

Acta Neurobiol Exp (Wars)

March 2024

Article Synopsis

* A study on female rats examined the effects of cannabidiol (CBD) on neuroinflammation by dividing them into four groups, including those receiving lipopolysaccharide (LPS) and CBD treatments.
* Results showed that CBD treatment improved neuron survival and reduced oxidative stress by regulating various proteins and synthesis pathways, reversing the damaging effects caused by LPS exposure.

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Lercanidipine ameliorated doxorubicin-induced neuroinflammation and maintained the expressions of choline acetyltransferase via enhancing the levels of PI3K/AKT/HIF1-α expressions.

Melike Dogan Unlu Sanem Asci Halil Asci Serife Agirca Tasan Ozlem Ozmen

Mol Biol Rep

February 2024

Background: Doxorubicin (DOX) may cause various neurological side effects in the brain. Lercanidipine (LRD) has antioxidant, anti-inflammatory, and anti-apoptotic properties. The aim of this study was to investigate the potential benefits of.

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