Alexithymia, Anger, Sensitivity to Mild Bodily Sensations and Personality Characteristics of Restless Legs Syndrome Patients: A Case-control Study.

Objective: This study aims to asess alexithymia, anger and its expression, sensitivity to bodily sensations, personality, and their relationship with the severity of the disease in patients with Restless Legs Syndrome.

Method: The study included 63 patients diagnosed with Restless Legs Syndrome and 63 age, gender and education matched controls. All participants were given, Toronto Alexithymia Scale, Somatosensory Amplification Scale, The State Trait Anger Scale and Temperament and Character Inventory.

The ameliorative effects of cannabidiol on methotrexate-induced neuroinflammation and neuronal apoptosis via inhibiting endoplasmic reticulum and mitochondrial stress.

Methotrexate (MTX) is an antineoplastic agent and has neurotoxic effects. It exerts its toxic effect on the brain by triggering inflammation and apoptosis. Cannabidiol (CBD) is an agent known for its antioxidant, anti-inflammatory effects in various tissues.