A multifactorial lens on risk factors promoting the progression of Alzheimer's disease.

The prevalence of Alzheimer's disease (AD) among adults has continued to increase over the last two decades, which has sparked a significant increase in research that focuses on the topic of "brain health." While AD is partially determined by a genetic predisposition, there are still numerous pathophysiological factors that require further research. This research requirement stems from the acknowledgment that AD is a multifactorial disease that to date, cannot be prevented.

Sand deposits reveal great earthquakes and tsunamis at Mexican Pacific Coast.

Globally, instrumentally based assessments of tsunamigenic potential of subduction zones have underestimated the magnitude and frequency of great events because of their short time record. Historical and sediment records of large earthquakes and tsunamis have expanded the temporal data and estimated size of these events. Instrumental records suggests that the Mexican Subduction earthquakes produce relatively small tsunamis, however historical records and now geologic evidence suggest that great earthquakes and tsunamis have whipped the Pacific coast of Mexico in the past.

Seismogeodetic P-wave Amplitude: No Evidence for Strong Determinism.

Whether the final properties of large earthquakes can be inferred from initial observations of rupture (deterministic rupture) is valuable for understanding earthquake source processes and is critical for operational earthquake and tsunami early warning. Initial (P-wave) characteristics of small to moderate earthquakes scale with magnitude, yet observations of large to great earthquakes saturate, resulting in magnitude underestimation. Whether saturation is inherent to earthquake dynamics or rather is due to unreliable observation of long-period signals with inertial seismic instrumentation is unclear.

Acoustic-propagation properties of methane clathrate hydrates from non-equilibrium molecular dynamics.

Given methane hydrates' importance in marine sediments, as well as the widespread use of seabed acoustic-signaling methods in oil and gas exploration, the elastic characterization of these materials is particularly relevant. A greater understanding of the properties governing phonon, sound, and acoustic propagation would help to better classify methane-hydrate deposits, aiding in their discovery. Recently, we have published a new nonequilibrium molecular-dynamics (NEMD) methodology to recreate longitudinal and transverse perturbations, observing their propagation through a crystalline lattice by various metrics, to study the underlying S- and P-wave velocities (achieving excellent agreement with experiment) [Melgar et al.

Characterizing large earthquakes before rupture is complete.

Whether earthquakes of different sizes are distinguishable early in their rupture process is a subject of debate. Studies have shown that the frequency content of radiated seismic energy in the first seconds of earthquakes scales with magnitude, implying determinism. Other studies have shown that recordings of ground displacement from small to moderate-sized earthquakes are indistinguishable, implying a universal early rupture process.

Amplitude effects on seismic velocities: How low can we go?

α-quartz is one of the most important SiO polymorphs because it is the basis of very common minerals, especially for seabed materials with geoscientific importance. The elastic characterization of these materials is particularly relevant when the properties governing phonon and sound propagation are involved. These studies are especially interesting for oil exploration purposes.

Geodetic Observations of Weak Determinism in Rupture Evolution of Large Earthquakes.

The moment evolution of large earthquakes is a subject of fundamental interest to both basic and applied seismology. Specifically, an open problem is when in the rupture process a large earthquake exhibits features dissimilar from those of a lesser magnitude event. The answer to this question is of importance for rapid, reliable estimation of earthquake magnitude, a major priority of earthquake and tsunami early warning systems.

Electronic Structure Studies on the Whole Keplerate Family: Predicting New Members.

A comprehensive study of the electronic structure of nanoscale molecular oxide capsules of the type [{M (M ) O } {M' O (μ-X)(μ-Y)(L )} ] is presented, where M,M'=Mo,W, and the bridging ligands X,Y=O,S, carried out by means of density functional theory. Discussion of the electronic structure of these derivatives is focused on the thermodynamic stability of each of the structures, the one having the highest HOMO-LUMO gap being M=W, M'=Mo, X=Y=S. For the most well-known structure M=M'=Mo, X=Y=O, [Mo O ] , the chemical bonding of several ligands to the {Mo O (μ-O) } linker moiety produces negligible effects on its stability, which is evidence of a strong ionic component in these bonds.

Anions coordinating anions: analysis of the interaction between anionic Keplerate nanocapsules and their anionic ligands.

Keplerates are a family of anionic metal oxide spherical capsules containing up to 132 metal atoms and some hundreds of oxygen atoms. These capsules holding a high negative charge of -12 coordinate both mono-anionic and di-anionic ligands thus increasing their charge up to -42, even up to -72, which is compensated by the corresponding counter-cations in the X-ray structures. We present an analysis of the relative importance of several energy terms of the coordinate bond between the capsule and ligands like carbonate, sulphate, sulphite, phosphinate, selenate, and a variety of carboxylates, of which the overriding component is contributed by solvation/de-solvation effects.

Direct Observation of the Formation Pathway of [Mo132] Keplerates.

The formation pathway of a closed spherical cluster [Mo132], starting from a library of building blocks of molybdate anions, has been reported. Electrospray ionization mass spectrometry, Raman spectroscopy, and theoretical studies describe the formation of such a complex cluster from a reduced and acidified aqueous solution of molybdate. Understanding the emergence of such an enormous spherical model cluster may lead to the design of new clusters in the future.

Physical applications of GPS geodesy: a review.

Geodesy, the oldest science, has become an important discipline in the geosciences, in large part by enhancing Global Positioning System (GPS) capabilities over the last 35 years well beyond the satellite constellation's original design. The ability of GPS geodesy to estimate 3D positions with millimeter-level precision with respect to a global terrestrial reference frame has contributed to significant advances in geophysics, seismology, atmospheric science, hydrology, and natural hazard science. Monitoring the changes in the positions or trajectories of GPS instruments on the Earth's land and water surfaces, in the atmosphere, or in space, is important for both theory and applications, from an improved understanding of tectonic and magmatic processes to developing systems for mitigating the impact of natural hazards on society and the environment.

Slip pulse and resonance of the Kathmandu basin during the 2015 Gorkha earthquake, Nepal.

Detailed geodetic imaging of earthquake ruptures enhances our understanding of earthquake physics and associated ground shaking. The 25 April 2015 moment magnitude 7.8 earthquake in Gorkha, Nepal was the first large continental megathrust rupture to have occurred beneath a high-rate (5-hertz) Global Positioning System (GPS) network.

Hydrophobic effect as a driving force for host-guest chemistry of a multi-receptor Keplerate-type capsule.

The effectiveness of the interactions between various alkylammonium cations and the well-defined spherical Keplerate-type {Mo132} capsule has been tracked by (1)H DOSY NMR methodology, revealing a strong dependence on the self-diffusion coefficient of the cationic guests balanced between the solvated and the plugging situations. Analysis of the data is fully consistent with a two-site exchange regime involving the 20 independent {Mo9O9} receptors of the capsule. Furthermore, quantitative analysis allowed us to determine the stability constants associated with the plugging process of the pores.