Publications by authors named "Melese M"

United Nations is standing for Sustainable Development Goal (SDG) 6 sets the agenda to address worldwide inequality in accessing safe water and improved sanitation facilities for all by 2030. However, governments in Africa seem unable to address the issue water and of sanitation facilities, since there are problems like increasing costs of sustaining existing water sources and the requirement to deliver new facilities ahead of time. Hence, this study aimed to investigate unimproved water sources and sanitation facilities geographical variation in Ethiopia using EDHS 2019 datasets.

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Introduction: Maternal undernutrition and inflammation in utero may significantly impact the neurodevelopmental potential of offspring. However, few studies have investigated the effects of pregnancy interventions on long-term child growth and development. This study will examine the effects of prenatal nutrition and infection management interventions on long-term growth and neurodevelopmental outcomes of offspring.

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Background: Smartphone use has become widespread and continues to grow rapidly. Medical students, already highly susceptible to sleep deprivation, may experience exacerbated issues due to smartphone usage, particularly at bedtime. Therefore, understanding the potential negative impacts of this behavior is crucial.

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Background Alcohol use disorder in people living with the human immunodeficiency virus is an important public health problem associated with high rates of HIV infection and lower antiretroviral treatment adherence. However, little is known about the prevalence of alcohol use disorders and its impact on ART adherence among people living with HIV/AIDS (PLWHA). Thus, this study aimed to evaluate the magnitude of alcohol use disorder and its impact on medication adherence among PLWHA attending the ART clinic.

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Background: Breast cancer is the most common cancer among females. Assessing self-screening practices for breast cancer patients is vital for developing targeted interventions. The current study aimed to assess self-screening practices for breast cancer and associated factors via the theory of planned behavior constructs among female students in Ethiopian universities.

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Article Synopsis
  • The study focuses on assessing academic performance among health science students in Eastern Ethiopian universities, utilizing cumulative GPA as a key measure of success, defined as a GPA of 3 or above.
  • Conducted with 924 undergraduate students, the research employed a cross-sectional design and collected data through a self-administered questionnaire, with statistical analysis performed using SPSS.
  • Results indicated that 70.5% of participants achieved good academic performance, with factors such as residence, lack of a sexual partner, test competence, time management, and strategic studying significantly associated with higher academic success.
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  • Most pregnancy-related complications in sub-Saharan Africa, particularly Ethiopia, are preventable; however, the incidence remains high due to limited data on the predictors of these complications.
  • The study utilized secondary data from a national longitudinal survey covering various Ethiopian regions to assess maternal health service usage and track outcomes for pregnant women over time.
  • Results indicated a 33.86% rate of obstetric complications during delivery, with significant risks including 15.73% of women experiencing bleeding and 4.14% having ruptured membranes.
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  • Effective communication between parents and adolescents is vital in reducing sexual health issues, particularly in culturally diverse settings like Ethiopia, where misinformation can lead to risky behaviors.
  • A study in Gondar town aimed to evaluate the level of parent-adolescent communication on sexual and reproductive health (SRH) among secondary students, using a structured questionnaire and statistical analysis to uncover influencing factors.
  • Results indicated that only 37.7% of adolescents communicated with their parents on these topics, with factors such as gender, grade level, living situation, and positive attitudes toward sexual health significantly impacting communication rates.
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Background: Erection Dysfunction, which primarily affects males older than 40 years, is the inability to regularly produce or retain a penile erection that is strong enough to satisfy sexual activity.

Objective: To evaluate knowledge, attitudes, and practices related to erectile dysfunction and its predictors among community pharmacy technicians in Gondar, Ethiopia.

Method: We conducted a cross-sectional descriptive study on pharmacy technicians in Gondar from June 1, 2022, to August 30, 2022.

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Background: The development of multidrug resistant strains of extended-spectrum β-lactamase-producing has become a global problem; therefore, the discovery of new antibacterial agents is the only available solution.

Objective: To improve and propose new compounds with antibacterial activity, the three-dimensional quantitative structure-activity relationship and molecular docking studies were carried out on Aztreonam analogs as inhibitors in DNA gyrase B.

Method: This study's 3D-Quantitative structure-activity relationship model was created using on the Comparative Molecular Field Analysis and the Comparative Molecular Similarity Indices Analysis.

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Background: Several studies were performed on transdermal (TD) insulin delivery in vitro and in vivo, and recently, the study groups included a clinical trial in humans. Therefore, this systematic review was conducted to get summary information about the effectiveness, safety, and preferability of TD insulin in comparison with subcutaneous insulin delivery.

Methods: We conducted a thorough search to find studies in the databases Cochrane Library, MEDLINE via PubMed, Web of Science Core Collection, EMBASE, Scopus, Hinari, Medlib, and Magiran until January 2024.

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Background: The conflict between the Ethiopian government and the Tigray People's Liberation Front (TPLF) in the Dabat district of Ethiopia has led to significant civilian casualties, instances of rape, sexual abuse, and property theft. These traumatic events contribute to the development of post-traumatic stress disorder (PTSD) among local residents. However, there is currently no available data on the prevalence of PTSD and its associated factors in this region.

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  • Head lice infestation is a significant issue among primary school children in low and middle-income countries, impacting their health and academic success, yet consistent data on its prevalence remains lacking.
  • This study reviewed 39 articles from various databases to analyze the prevalence and risk factors associated with head lice among affected children, adhering to systematic review guidelines.
  • The findings revealed that nearly 20% of children were infested, with girls being 3.71 times more likely to have head lice compared to boys, indicating specific demographics may be more affected.
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  • Good-quality sleep is characterized by minimal disturbances, sufficient duration, and proper progression through sleep stages, yet sleep issues are common among individuals living with HIV/AIDS, particularly in sub-Saharan Africa.
  • A systematic review and meta-analysis of 15 studies with 5176 participants found that nearly half (49.32%) of HIV/AIDS patients in SSA experience poor sleep quality, which significantly impacts their treatment adherence and quality of life.
  • Key factors linked to poor sleep quality included high levels of depression and lower CD4 cell counts, highlighting the need for better support and intervention strategies for affected individuals.
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  • Ethiopia faces significant undernutrition challenges, especially for children under 5, exacerbated by ongoing conflicts and a lack of humanitarian aid.
  • A study conducted from January to March 2023 involving 400 under-5 children revealed a 12% prevalence of undernutrition, with high rates of stunting, underweight, and wasting among affected children.
  • Environmental factors significantly impacting undernutrition included sanitation practices, mother's occupation and living conditions, water treatment methods, and hygiene habits.
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Background: Poor sleep quality is a common concern in chronic kidney disease (CKD) patients, which can accelerate the progression of chronic renal disease and negatively impact their health-related quality of life, potentially leading to greater morbidity and mortality rates. It can also have an effect on the immune system, cognitive function, and emotional well-being of CKD patients. Furthermore, poor sleep quality may contribute to drug noncompliance and decreased participation in the entire treatment plan.

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Background: The maternal continuum of care (CoC) is a cost-effective approach to mitigate preventable maternal and neonatal deaths. Women in developing countries, including Tanzania, face an increased vulnerability to significant dropout rates from maternal CoC, and addressing dropout from the continuum remains a persistent public health challenge.

Method: This study used the 2022 Tanzania Demographic and Health Survey (TDHS).

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Background: Generally, people with type 2 diabetes mellitus in various countries experience a significant rate of sensorineural hearing impairment. Nonetheless, there is scant evidence of sensorineural hearing impairment among type 2 diabetes mellitus patients in Northwest Ethiopian. Therefore, the objective of this study was to evaluate the occurrence rate and contributing factors of sensorineural hearing impairment in type 2 diabetics at comprehensive and specialized referral hospitals in Northwest Ethiopia.

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  • HIV/AIDS significantly affects women's reproductive health in sub-Saharan Africa, prompting a study at the University of Gondar to evaluate knowledge and practices related to family planning among HIV-positive women.
  • Conducted through interviews with structured questionnaires, the study collected data on knowledge, attitudes, and practices from 328 women, employing logistic regression for analysis.
  • Results showed that while knowledge about modern contraceptives and safer conception was high (93% and 94% respectively), only 30.2% were aware of dual contraceptive methods, and contraceptive use was primarily through injectables (34.2%).
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Tuberculosis (TB) remains a significant public health concern, particularly in low-resource settings. The treatment outcome is a crucial indicator of the effectiveness of TB treatment programs. Assessing the current treatment outcome and its associated factors is essential for improving patient care and reducing the spread of TB.

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Common mental disorders (CMDs) are a wide term that includes disorders like depression, anxiety, and somatic manifestations. Chronic kidney disease (CKD) patients are at high risk of developing a common mental disorders, which leads to a lower survival rate, poor clinical outcome, longer hospitalization, increased health-care utilization, difficulty adhering to medications, an increased risk of initiation of dialysis, poor quality of life, and an increased risk of mortality. However, there is limited study done related to common mental disorders and associated factors among chronic kidney disease patients in Ethiopia.

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Background: Refugee populations are forcibly displaced from their homes as a consequence of natural disasters and armed conflicts. Eritreans, initially displaced to the Maiayni camp within the Tigray region, have faced further relocation to Dabat town due to the conflict between the Tigray People Liberation Front (TPLF) and Ethiopian government forces. Subsequently, another conflict has arisen between the Amhara Popular Force (Fano) and Ethiopian government forces in Dabat town, disrupting its stability.

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Introduction: Poison is a substance that can hurt or cause dysfunction in the body due to its chemical action. Poisoning related to pesticides used in agriculture is a major public health issue in developing countries. However, there is a limited epidemiological data on poisoning in Ethiopia.

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