Publications by authors named "Melek Aslan Kayiran"

Article Synopsis
  • Psoriasis patients on biologic therapy have a significantly higher density of Demodex mites compared to those who are treatment-naive or using topical treatments.
  • The study found that Demodex density was notably increased on both cheeks and overall facial regions in the biologic group, with significant statistical differences.
  • Results suggest that biologic treatments may affect immune response, leading to an increase in Demodex density, warranting further investigation into how various biologic agents influence this relationship.
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Background: Human Demodex mites, Demodex folliculorum and Demodex brevis, are microorganisms that reside in the pilosebaceous units, usually without causing symptoms. Phototherapy has been linked to demodicosis in previous studies. We aimed to determine whether there was an increase in the frequency of demodicosis and Demodex density after 20 phototherapy sessions.

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Introduction: Acne occurring in adults over the age of 25 years is known as acne tarda or adult acne. Three types of adult acne are recognized: persistent, late-onset, and recurrent acne. Most studies do not compare the characteristics between the three variants.

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Background: Since psoriasis is a chronic disease, it is not recommended to discontinue the treatment agents used. However, in real life, the treatment of psoriasis patients may be interrupted for various reasons. During the pandemic period, the treatment of many patients was also interrupted.

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Introduction: Due to the chronic recurrent nature of psoriasis vulgaris (PV) and lack of definitive treatment for the disease, patients often resort to alternative treatments. Physicians seem to have low awareness of this issue.

Objectives: To elicit the perceptions of 1,621 PV patients on complementary and alternative medicine (CAM) and examine factors reported to worsen PV.

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Background: Acne vulgaris (AV) is among the common skin diseases for which patients refer to complementary and alternative medicine (CAM).

Aims And Objectives: To investigate the approaches to CAM methods and factors believed to increase the disease in 1,571 AV patients.

Materials And Methods: The sociodemographic characteristics of the patients and disease severity according to the Food and Drug Administration criteria were recorded.

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Introduction: Psoriasis significantly affects the patients quality of life, which often leads patients to seek online information about this disease.

Objectives: To explore the habits of patients with psoriasis related to their use of social media (SM) and the internet to obtain information about their disease.

Methods: 1,520 patients completed the survey and the Dermatology Life Quality Index (DLQI) questionnaire.

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Background Knowledge about cutaneous microbiota in psoriasis vulgaris and seborrheic dermatitis is limited, and a comparison of microbiota in the two diseases was not yet previously undertaken. Aims/Objectives This study aimed to compare the scalp lesional and non-lesional microbiota in psoriasis vulgaris and seborrheic dermatitis with that in a healthy control group. Methods Fifty samples were taken with sterile swabs from patients' and controls' scalps, and 16S rRNA gene sequencing analyses were performed.

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Article Synopsis
  • - Papulosquamous diseases are a group of skin disorders characterized by papules and plaques, which can appear in various shapes, including ring-shaped (annular) forms.
  • - Some skin disorders like pityriasis rosea and subcorneal pustular dermatosis typically appear in annular patterns, while others, such as psoriasis vulgaris and seborrheic dermatitis, can start or change into these shapes.
  • - The text reviews common papulosquamous diseases with annular lesions, detailing their appearances and differentiating them from similar conditions.
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Background: Skincare products and cosmetic procedures are used as an adjunct or complementary to conventional drug therapy for acne vulgaris (AV).

Objective: To evaluate the use of skincare products and the frequency of cosmetic procedures in AV treatment.

Methods: A total of 1,755 patients with AV completed the survey prepared by the researchers and the Cardiff Acne Disability Index (CADI) questionnaire.

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The emergence of the coronavirus disease 2019 pandemic has led to a change in the whole world order. The key actors and occupational groups most at risk during this period have been health care professionals. In this pandemic, we, as dermatologists, also have many responsibilities regarding patients, ourselves, and society.

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Background: The rate of cosmetic procedures and use of skincare products is considered to be affected during the pandemic period; however, this has not been investigated yet.

Objective: To determine whether the ongoing pandemic has changed people's habits related to skincare products and cosmetic procedures.

Methods: We conducted a multicenter survey study covering both private and public hospitals.

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Background: Acne vulgaris (AV) may affect external appearance and significantly deteriorate the quality of life of patients. Therefore, patients make various inquiries about their disease and seek treatment options.

Aims: To investigate the social media usage habits of patients with AV concerning their diseases, and their recommendations for dermatologists related to social media use.

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Article Synopsis
  • Researchers studied how long patients with plaque-type psoriasis could stay on a medication called methotrexate (MTX) to see if it works well over time.
  • They looked at 3,512 patient records and found that, on average, people stayed on MTX for about 15 months, with many stopping due to side effects like nausea or because it wasn’t helping them.
  • Doctors need to monitor patients for 16-24 weeks before deciding if MTX is working well to reduce the chances of them stopping the treatment early.
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Acitretin is a nonimmunosuppresive systemic agent used in the treatment of psoriasis. Despite its frequent use, research on drug survival and adverse effects is limited. This study aims to evaluate drug survival, factors associated with survival, and adverse effects.

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Antibiotic resistance in acne was first observed in the 1970s, and since the 1980s has become a major concern in dermatologic daily practice. The mechanisms for this type of resistance include biofilm formation that promotes virulence and the transmission of resistant bacterial strains. Genetic mutations with modification of ribosomal RNA, alteration in efflux pumps, and enzymatic inactivation are able to create resistance to tetracyclines and macrolides.

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Acne vulgaris (AV) is a skin disease that is commonly seen and causes scar formation especially when left untreated. It can cause serious psychological comorbidities due to the intense involvement of appeared areas such as face and also being common in adolescence in which the body perception is not yet well established. Although psychiatric comorbidities frequently accompany AV patients in dermatology, they almost never directed to dermatology-psychiatry liaison clinics.

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Acne vulgaris (AV) is a common skin disease that is treated both with dermatologists and family physicians (FPs) with different strategies. To assess the antibiotics that are frequently preferred in AV treatment, and the differences between the FPs and dermatologists in treatment were investigated. The physicians were informed about the study, and sent over the internet a multiple-choice questionnaire that consists of 29 questions in total.

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Immunosuppressive and immunomodulatory therapies are important in dermatology, but indications are influenced by SARS-CoV-2. We will focus on skin disorders such as autoimmune connective tissue disorders, neutrophilic dermatoses, and vasculitis. Immunomodulators such as colchicine and antimalarials can easily be preferred taking their beneficial effects on COVID-19 into consideration and also given their wide spectrum of action.

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Background/aim: Cutaneous adnexal tumors (CAT) are rare tumors originating from the adnexal epithelial parts of the skin. Due to its clinical and histopathological characteristics comparable with other diseases, clinicians and pathologists experience difficulties in its diagnosis.We aimed to reveal the clinical and histopathological characteristics of the retrospectively screened cases and to compare the prediagnoses and histopathological diagnoses of clinicians.

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