Machine Learning Prediction for Prognosis of Patients With Aortic Stenosis.

Background: Aortic valve stenosis of any degree is associated with poor outcomes.

Objectives: The authors aimed to develop a risk prediction model for aortic stenosis (AS) prognosis using machine learning techniques.

Methods: A prognostic algorithm was developed using an AS registry of 10,407 patients undergoing echocardiography between 2008 and 2020.

Subclinical Myocardial Dysfunction in Patients Recovered from COVID-19 Disease: Correlation with Exercise Capacity.

Aims: Myocardial abnormalities are common during COVID-19 infection and recovery. We examined left (LV) and right (RV) ventricular longitudinal strain in patients who had recovered from COVID-19 and assessed the correlation with exercise capacity.

Methods And Results: One hundred and eighty-four consecutive patients with history of COVID-19 disease who had been referred to rest or stress echocardiography because of symptoms, mainly dyspnea and chest pain, were included in the study.

Transthyretin cardiac amyloidosis in patients after TAVR: clinical and echocardiographic findings and long term survival.

Aims: The aim of this study was to examine the prevalence of amyloid transthyretin (ATTR) cardiac amyloidosis in patients 1-2 years after trans-catheter aortic valve replacement (TAVR) and to assess their clinical and echocardiographic outcome and long-term survival.

Methods And Results: We enrolled 88 patients, mean age 81 years, 534 (390-711) days after TAVR. Patients underwent a Tc99m-PYP scintigraphy for the diagnosis of ATTR cardiac amyloidosis.

Wild-type TTR amyloidosis among patients with unexplained heart failure and systolic LV dysfunction.

Aim: Transthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized cause of heart failure (HF) with preserved left ventricular ejection fraction (LVEF), typically presenting as restrictive cardiomyopathy. The potential co-existence of ATTR-CA with systolic heart failure has not been studied. The aim of this study is to describe the prevalence of ATTR-CA and its clinical characteristics in HF patients with reduced LVEF.

Urea level is an independent predictor of mortality in patients with severe aortic valve stenosis.

Introduction: Severe aortic stenosis (AS) is the most common valvular heart disease in the western world. Various factors are related to severe AS prognosis, including chronic kidney disease. The aim of this study was to evaluate the prognostic value of urea level in patients with severe AS.

The Association Between Longitudinal Strain at Rest and Stress and Outcome in Asymptomatic Patients With Moderate and Severe Aortic Stenosis.

Background: Calcific aortic stenosis (AS) is a progressive disease, and once moderate AS is present, the likelihood of symptom onset within 5 years is significant. The aim of this study was to determine the incremental value of global longitudinal strain (GLS) and basal longitudinal strain (BLS) at rest and during exercise on outcomes among asymptomatic patients' with moderate and severe AS.

Methods: Seventy-five patients with isolated, asymptomatic AS and preserved left ventricular function were retrospectively enrolled and underwent symptom-limited exercise echocardiography.

Circulating regulatory T cells in patients with aortic valve stenosis: Association with disease progression and aortic valve intervention.

Background: Severe aortic valve stenosis (AS) accounts for considerable morbidity and death, especially in older patients. There is increasing evidence to suggest a role for immune modulating cells in aortic valve (AV) degeneration. Regulatory T cells (Tregs) tune down inflammation.

Circulating CD14(+) monocytes in patients with aortic stenosis.

Background: Calcific aortic stenosis (AS) is an active process sharing similarities with atherosclerosis and chronic inflammation. The pathophysiology of AS is notable for three cardinal components: inflammation, fibrosis and calcification. Monocytes play a role in each of these processes.

Circulating Endothelial Progenitor Cells and Clinical Outcome in Patients with Aortic Stenosis.

Background: Aortic stenosis (AS) is the most common valvular disease. Endothelial progenitor cells (EPCs) have a role in the repair of endothelial surfaces after injury. Reduced numbers of EPCs are associated with endothelial dysfunction and adverse clinical events, suggesting that endothelial injury in the absence of sufficient repair by circulating EPCs promotes the progression of vascular and possibly valvular disorders.

Stroke volume adjusted to afterload for assessment of cardiac performance in patients with severe aortic stenosis and preserved left ventricular ejection fraction.

Objectives: The aim of this study was to evaluate the relationship between valvular resistance and stroke volume (SV) and to assess SV adequacy to afterload in patients with severe aortic stenosis (AS) and normal left ventricular ejection fraction (LVEF).

Methods: We assessed clinical characteristics and echocardiographic parameters in 44 patients with isolated severe AS and preserved LVEF. LV end-diastolic pressure (LVEDP) and LV mean diastolic pressure (LVMDP) were measured by cardiac catheterization.

Low circulating monocyte count is associated with severe aortic valve stenosis.

Background: The pathophysiology of aortic stenosis (AS) involves inflammatory features including infiltration of the aortic valve (AV) by activated macrophages and T cells, deposition of lipids, and heterotopic calcification.

Objectives: To evaluate the correlation between white blood cell (WBC) differential count and the occurrence and progression of AS.

Methods: We identified in our institutional registry 150 patients with AS who underwent two repeated echo studies at least 6 months apart.

[Effects of amitriptyline on the contractile function of the myocardium. Dobutrex in the role of a positive inotropic agent].

Study of the effect of a tricyclic antidepressant amitriptyline on an isolated papillary muscle of the rat left ventricle showed a decrease of the contractility due to depression of the potential of action and the slow calcium channels, as well as decreased rate and prolongation of contraction caused by impairment of calcium reabsorption from the sarcoplasma. Injection of dobutrex after amitriptyline has a positive inotropic effect by completely removing the disorders in the time parameters of contraction.

[Variants of drug treatment of disorders of the conductivity in the sinoatrial zone and atrioventricular junction in patients with acute clofelin poisoning].

The paper presents the results of electrophysiological studies of the function of the sinus node, sinoatrial and atrioventricular conduction in 62 patients with acute clofelin poisoning and of drug correction of the said disorders. Atropine, asthmopent, dobutrex, and butyroxan were used. Toxicogenic depression of the sinus node and conduction disorders in the sinoatrial zone and atrioventricular junction were detected, with blocking of the entrance and exit or isolated blocking of the exit forming in the sinoatrial zone in some patients.

[The clinical characteristics and diagnosis of lesions of the upper third of the vertebral arteries].

An analysis of the clinical symptoms of abnormalities in the upper third vertebral arteries made it possible to identify 4 stages of their development. The tunnel-compression syndrome was found to underline the abnormalities. It was established that Doppler ultrasonic imaging and vein spondylography were the most informative diagnostic techniques.

[The functional status of the sinoatrial node and the atrioventricular conductivity in patients with acute klofelin poisoning].

Using diagnostic transesophageal electrical cardiostimulation, sinus node function, sinoatrial and atrioventricular conductivity have been studied in 30 patients with acute clophelin poisoning. The results of pharmacological tests with atropine and alupent are presented. Control examinations have been performed on discharge.