Procedure for Organizing a Post-FDA-approval Evaluation of Antidepressants.

Purpose: The study reports the construction of a cohort used to study the effectiveness of antidepressants.

Methods: The cohort includes experiences of 3,678,082 patients with depression in the United States on antidepressants between January 1, 2001, and December 31, 2018. A total of 10,221,145 antidepressant treatment episodes were analyzed.

Effectiveness of common antidepressants: a post market release study.

Background: This study summarizes the experiences of patients, who have multiple comorbidities, with 15 mono-treated antidepressants.

Methods: This is a retrospective, observational, matched case control study. The cohort was organized using claims data available through OptumLabs for depressed patients treated with antidepressants between January 1, 2001 and December 31, 2018.

A surrogate measure for patient reported symptom remission in administrative data.

Background: In real-world pragmatic administrative databases, patient reported remission is often missing.

Objective: We evaluate if, in administrative data, five features of antidepressant use patterns can replace patient-reported symptom remission.

Method: We re-examined data from Sequence Treatment Alternatives to Relieve Depression (STAR*D) study.