Integrative public data-mining pipeline for the validation of novel independent prognostic biomarkers for lung adenocarcinoma.

We aimed to develop a candidate-based integrative public data mining strategy for validation of novel prognostic markers in lung adenocarcinoma. An approach integrating meta-analyses of publicly available clinical information linked RNA expression, gene copy number and mutation datasets combined with independent immunohistochemistry and survival datasets. After validation of pipeline integrity utilizing data from the well-characterized prognostic factor Ki-67, prognostic impact of the calcium- and integrin-binding protein, CIB1, was analyzed.

The P2-receptor-mediated Ca signalosome of the human pulmonary endothelium - implications for pulmonary arterial hypertension.

Dysfunction of the pulmonary endothelium is associated with most lung diseases. Extracellular nucleotides modulate a plethora of endothelial functions in the lung such as vessel integrity, vasodilatation, inflammatory, and thrombotic responses as well as survival and DNA repair, mostly via Ca signaling pathways. However, a comprehensive analysis of the molecular components of the underlying P2 receptor-mediated Ca signaling pathways in the lung has not been conducted so far.

Evaluative priming in a semantic flanker task: ERP evidence for a mutual facilitation explanation.

In semantic flanker tasks, target categorization response times are affected by the semantic compatibility of the flanker and target. With positive and negative category exemplars, we investigated the influence of evaluative congruency (whether flanker and target share evaluative valence) on the flanker effect, using behavioral and electrophysiological measures. We hypothesized a moderation of the flanker effect by evaluative congruency on the basis of the assumption that evaluatively congruent concepts mutually facilitate each other's activation (see Schmitz & Wentura in Journal of Experimental Psychology: Learning, Memory, and Cognition 38:984-1000, 2012).

Evaluative priming of naming and semantic categorization responses revisited: a mutual facilitation explanation.

The evaluative priming effect (i.e., faster target responses following evaluatively congruent compared with evaluatively incongruent primes) in nonevaluative priming tasks (such as naming or semantic categorization tasks) is considered important for the question of how evaluative connotations are represented in memory.

P50 sensory gating and smoking in the general population.

P50 gating is a major functional biomarker in research on schizophrenia and other psychiatric conditions with high smoking prevalence. It is used as endophenotype for studying nicotinic systems genetics and as surrogate endpoint measure for drug development of nicotinic agonists. Surprisingly, little is known about P50 gating in the general population and the relationship to smoking-related characteristics.