Publications by authors named "Melanie Mendonca"
Article Synopsis
- This study investigates the effects of excessive fluoride on the microstructure of dentine in mice, as previous research has mostly focused on its impact on enamel.* -
- Male C57BL6/J mice were divided into four groups, receiving different fluoride concentrations in their drinking water for six weeks, after which various analyses were conducted to evaluate enamel and dentine properties.* -
- Results indicated that high fluoride exposure (50-125 ppm) led to enamel hypoplasia, reduced dentine mineral density, and changes in the structure of the dentine-pulp complex, demonstrating significant negative effects of excessive fluoride consumption.*
Article Synopsis
- - Fluoride ingestion during tooth development can lead to dental fluorosis, and it activates histone acetyltransferase (HAT), which modifies the protein p53 and contributes to fluoride toxicity in specific mouse cells (LS8).
- - The study showed that fluoride modifies histone acetylation, altering gene expression in LS8 cells, as evidenced by increased acetylation levels of certain genes and corresponding mRNA expression when treated with fluoride.
- - This research is the first to highlight that fluoride treatment can lead to epigenetic changes through H3 acetylation, indicating a need for further investigation into how fluoride affects enamel development on a genetic level.
Article Synopsis
- The study evaluates the mechanical property of microhardness in dental enamel, dentin, and bone, focusing on diseases like dental fluorosis and periodontitis using advanced imaging techniques like micro-CT and scanning electron microscopy.
- It highlights the need for standardization of microhardness measurement methods, as existing discrepancies can impact the consistency and accuracy of the findings across studies.
- The research presents a newly developed standardized protocol for analyzing microhardness in tooth and alveolar bone, which includes detailed procedures for sample preparation and measurement in rodent disease models.
Executive deficits and impulsiveness are extensively reported in juvenile myoclonic epilepsy (JME). Previous literature suggests that intelligence may mediate these deficits. In this study, we evaluated and compared the performance of adults with JME with high and low intelligence quotient (IQ) and controls on tasks for executive function (EF) and impulsive traits.
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